(Rac)-Tezacaftor

• 常用名: (Rac)-Tezacaftor
• 英文名: (Rac)-Tezacaftor
• CAS号: 1226709-85-8
• 分子量: 520.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₇F₃N₂O₆
• 熔点: N/A
• 闪点: N/A

(Rac)-Tezacaftor用途

(Rac)-Tezacaftor((Rac,-VX-661)是特扎卡福(HY-15448)的外消旋体。Tezacaftor是F508del CFTR校正器。(Rac)-Tazacaftor可用于囊性纤维化的研究[1]。

(Rac)-Tezacaftor名称

• 英文名: (Rac)-Tezacaftor

(Rac)-Tezacaftor生物活性

• 描述: (Rac)-Tezacaftor((Rac,-VX-661)是特扎卡福(HY-15448)的外消旋体。Tezacaftor是F508del CFTR校正器。(Rac)-Tazacaftor可用于囊性纤维化的研究[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Keating D, et al. VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.

(Rac)-Tezacaftor物理化学性质

• 分子式: C₂₆H₂₇F₃N₂O₆
• 分子量: 520.50
• InChIKey: MJUVRTYWUMPBTR-UHFFFAOYSA-N
• SMILES: CC(C)(CO)c1cc2cc(NC(=O)C3(c4ccc5c(c4)OC(F)(F)O5)CC3)c(F)cc2n1CC(O)CO