乙溴替丁

• 常用名: 乙溴替丁
• 英文名: Ebrotidine
• CAS号: 100981-43-9
• 分子量: 477.423
• 密度: 1.7±0.1 g/cm3
• 沸点: 672.3±65.0 °C at 760 mmHg
• 分子式: C₁₄H₁₇BrN₆O₂S₃
• 熔点: N/A
• 闪点: 360.4±34.3 °C

乙溴替丁用途

Ebrotidine(FI 3542)是竞争性H2受体拮抗剂,Ki为127.5nM,具有抗分泌活性,可用于胃保护。

乙溴替丁名称

• 中文名: 乙溴替丁
• 英文名: N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide

乙溴替丁生物活性

• 描述: Ebrotidine(FI 3542)是竞争性H2受体拮抗剂,Ki为127.5nM,具有抗分泌活性,可用于胃保护。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Agut J, Sánchez JC, Sacristán A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9.

  [2]. Palop D, Agut J, Márquez M, Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.

  [3]. Konturek SJ, Kwiecien N, Sito E, Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans. Scand J Gastroenterol. 1993 Dec;28(12):1047-50.

  [4]. Piotrowski J, Yamaki K, Morita M, Ebrotidine--a new H2-receptor antagonist with mucosal strengthening activity. Biochem Int. 1992 Mar;26(4):659-67.

乙溴替丁物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 672.3±65.0 °C at 760 mmHg
• 分子式: C₁₄H₁₇BrN₆O₂S₃
• 分子量: 477.423
• 闪点: 360.4±34.3 °C
• 精确质量: 475.975830
• PSA: 195.24000
• LogP: 3.37
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.740
• 储存条件: 2-8℃

乙溴替丁毒性和生态

乙溴替丁安全信息

• 海关编码: 2942000000

乙溴替丁海关

• 海关编码: 2942000000

乙溴替丁英文别名

• 4-Bromo-N-[(E)-({2-[({2-[(diaminomethylene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}imino)methyl]benzenesulfonamide
• Ebrotidina [Spanish]
• Ebrotidina
• Benzenesulfonamide, 4-bromo-N-[(E)-[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]imino]methyl]-
• 4-bromo-N-{(E)-[(2-{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}ethyl)amino]methylidene}benzenesulfonamide
• Ebrotidine
• Benzenesulfonamide,N-(((2-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)-4-bromo-,(E)
• n-p-bromobenzenesulfonyl-n'-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]formamidine
• Ebrotidinum [Latin]
• Ebrotiding
• N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
• FI-3542
• p-Bromo-N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]benzenesulfonamide
• Ulsanic
• Ebrotidinum