138-92-1

• 常用中文名：2-(3-吡唑基)乙胺二盐酸盐
• 常用英文名：Betazole dihydrochloride
• CAS号：138-92-1
• 分子式：C₅H₁₁Cl₂N₃
• 分子量：184.06700
• 相关类别： 原料药 诊断用药 器官功能检查剂
• 发布时间：2018-04-13 08:00:00
• 更新时间：2024-01-06 19:25:22
• Betazole (Ametazole) dihydrochloride 是一种吡唑类组胺,是一种口服活性 H2 受体激动剂。Betazole dihydrochloride 诱导胃酸分泌,导致胆总管压力立即显著升高。Betazole dihydrochloride 被用作一种被称为 histalog 的诊断剂,用于研究胃酸分泌能力。

名称

• 中文名: 盐酸倍他唑
• 英文名: betazole dihydrochloride
• 英文别名: 1h-pyrazole-3-ethanamine,dihydrochloride; BETAZOLE HYDROCHLORIDE (200 MG); 3-(2-aminoethyl)-pyrazoldihydrochloride; histalog; [2-(1H-Pyrazol-3-yl)ethyl]amine dihydrochloride; ametazoledihydrochloride; Betazole hydrochloride; 2-(1(2)H-pyrazol-3-yl)-ethylamine,dihydrochloride; gastramine; 2-(1(2)H-Pyrazol-3-yl)-aethylamin,Dihydrochlorid; 3-(2-aminoethyl)pyrazole,dihydrochloride; Histimin

物化性质

• 沸点: 284.1ºC at 760mmHg
• 熔点: 224-226°
• 分子式: C₅H₁₁Cl₂N₃
• 分子量: 184.06700
• 闪点: 150.3ºC
• 精确质量: 183.03300
• PSA: 54.70000
• LogP: 2.21520
• 蒸汽压: 0.00303mmHg at 25°C
• 储存条件: 2-8°C
• 分子结构:

  1、 摩尔折射率：31.86

  2、 摩尔体积（cm³/mol）：97.4

  3、 等张比容（90.2K）：266.6

  4、 表面张力（dyne/cm）：56.0

  5、 极化率（10-24cm3）：12.63

生物活性

• 描述: Betazole (Ametazole) dihydrochloride 是一种吡唑类组胺,是一种口服活性 H2 受体激动剂。Betazole dihydrochloride 诱导胃酸分泌,导致胆总管压力立即显著升高。Betazole dihydrochloride 被用作一种被称为 histalog 的诊断剂,用于研究胃酸分泌能力。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点:

  H2 Receptor

• 体外研究: 盐酸倍他唑(Ametazole)是一种弱组胺激动剂,对H2受体有相对选择性,H1活性最低。盐酸倍他唑诱导胃抑制肽(GIP)分泌[1]。
• 参考文献:

  [1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521.

  [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382.

  [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ5600000 CHEMICAL NAME : Pyrazole, 3-(2-aminoethyl)-, dihydrochloride CAS REGISTRY NUMBER : 138-92-1 LAST UPDATED : 199404 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C5-H9-N3.2Cl-H MOLECULAR WEIGHT : 184.09 WISWESSER LINE NOTATION : T5MNJ C2Z &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Ocular SPECIES OBSERVED : Human - woman DOSE/DURATION : 740 ug/kg/37D-I TOXIC EFFECTS : Behavioral - wakefulness Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) REFERENCE : AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,275,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Ocular SPECIES OBSERVED : Human - man DOSE/DURATION : 86 ug/kg/6D-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea REFERENCE : AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 102,274,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 860 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 122,685,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 803 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,749,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83995 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 66 (estimated)

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933199090

海关

海关编码	2933199090
中文概述	2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%