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465-65-6

465-65-6结构式

常用中文名：纳洛酮
常用英文名：Naloxone
CAS号：465-65-6
分子式：C₁₉H₂₁NO₄
分子量：327.37
相关类别：原料药专科用药解毒药
发布时间：2018-08-06 19:54:23
更新时间：2024-01-04 19:00:18
Naloxone 是 Opioid receptor 的拮抗剂。Naloxone 可减轻阿片类药物过量引起的呼吸抑制。Naloxone 可能会引起肺水肿和心律失常。

中文名	纳洛酮
英文名	naloxone
中文别名	(5alpha)-3,14-二羟基-17-丙-2-烯-1-基-4,5-环氧吗啡烷-6-酮
英文别名	[14C]-Naloxone [3H]-Naloxone Narcanti Nalone Naloxonum EN 1530 base (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Narcon l-Naloxone Narcan n-Allylnoroxymorphone Naloxona

描述	Naloxone 是 Opioid receptor 的拮抗剂。Naloxone 可减轻阿片类药物过量引起的呼吸抑制。Naloxone 可能会引起肺水肿和心律失常。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体信号通路 >> 神经信号通路 >> 阿片受体研究领域 >> 神经疾病
参考文献	[1]. van Dorp E, et al. Naloxone treatment in opioid addiction: the risks and benefits. Expert Opin Drug Saf. 2007 Mar;6(2):125-32.

CHEMICAL NAME :: Morphinan-6-one, 4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ CQ JQ P2U1

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,519,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4324 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 306 (estimated) No. of Female Employees: 121 (estimated)

符号	GHS02, GHS06, GHS08
信号词	Danger
危害声明	H225-H301 + H311 + H331-H370
警示性声明	P210-P260-P280-P301 + P310-P311
危害码 (欧洲)	F,T
风险声明 (欧洲)	11-23/24/25-39/23/24/25
安全声明 (欧洲)	7-16-36/37-45
危险品运输编码	UN1230 - class 3 - PG 2 - Methanol, solution