20410-95-1

20410-95-1结构式

描述	6-Alpha Naloxol(Alpha-Naloxol)是opioid拮抗剂,naloxone的代谢物。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体信号通路 >> 神经信号通路 >> 阿片受体研究领域 >> 神经疾病
参考文献	[1]. Weinstein SH, et al. Metabolites of naloxone in human urine. J Pharm Sci. 1971 Oct;60(10):1567-8. [2]. Csaba Simon, et al. Stereoselective synthesis of β-naltrexol, β-naloxol β-naloxamine, β-naltrexamine and related compounds by the application of the mitsunobu reac. Tetrahedron Volume 50, Issue 32, 1994, Pages 9757–9768. [3]. Schulteis G, et al. Relative potency of the opioid antagonists naloxone and 6-alpha-naloxol to precipitate withdrawal from acute morphine dependence varies with time post-antagonist. Pharmacol Biochem Behav. 2009 Mar;92(1):157-63.

465-65-6

~93%

20410-95-1

文献：MALLINCKRODT INC. Patent: WO2008/137672 A1, 2008 ; Location in patent: Page/Page column 25 ;

106-95-6

58477-92-2

20410-95-1

文献：Rezaie, Robert; Bailey, Timothy S. Patent: US2010/36128 A1, 2010 ; Location in patent: Page/Page column 7 ;

116388-84-2

~63%

20410-95-1

文献：Hosztafi, Sandor; Berenyi, Sandor; Toth, Geza; Makleit, Sandor Monatshefte fuer Chemie, 1992 , vol. 123, # 5 p. 435 - 442

465-65-6

53154-12-4

20410-95-1

文献：Hahn; Fishman Journal of Organic Chemistry, 1975 , vol. 40, # 1 p. 31 - 34

67210-64-4

20410-95-1

文献：Hosztafi, Sandor; Berenyi, Sandor; Toth, Geza; Makleit, Sandor Monatshefte fuer Chemie, 1992 , vol. 123, # 5 p. 435 - 442

116499-16-2

20410-95-1

文献：Hosztafi, Sandor; Berenyi, Sandor; Toth, Geza; Makleit, Sandor Monatshefte fuer Chemie, 1992 , vol. 123, # 5 p. 435 - 442