314-03-4

• 常用中文名：匹美噻吨
• 常用英文名：Pimethixene
• CAS号：314-03-4
• 分子式：C₁₉H₁₉NS
• 分子量：293.42600
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 组胺受体
• 发布时间：2018-03-02 08:00:00
• 更新时间：2024-01-02 12:33:55
• Pimethixene是一种抗组胺剂和抗胆碱能剂, 常用于治疗多动症，焦虑, 睡眠障碍, 和过敏。

名称

• 中文名: 匹美噻吨
• 英文名: pimethixene
• 英文别名: Calmixene; 10-(1-methyl-4-piperidylidene)dibenzo[b,e]thiane; 1-methyl-4-(9H-thioxanthen-9-ylidene)-piperidine; 1-methyl-4-thioxanthen-9-ylidene-piperidine; Calmixen; 9-(N-methyl-piperidyliden-4-yl)-thioxanthene; 9-(N-methyl-piperidyliden-4)-thioxanthene

物化性质

• 密度: 1.192g/cm3
• 沸点: 439.7ºC at 760mmHg
• 分子式: C₁₉H₁₉NS
• 分子量: 293.42600
• 闪点: 219.7ºC
• 精确质量: 293.12400
• PSA: 28.54000
• LogP: 4.61660
• 折射率: 1.661
• 储存条件: 2-8℃

生物活性

• 描述: Pimethixene是一种抗组胺剂和抗胆碱能剂, 常用于治疗多动症,焦虑, 睡眠障碍, 和过敏。
• 相关类别:
  信号通路 >> 神经信号通路 >> 疼痛
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TN1575000 CHEMICAL NAME : Piperidine, 1-methyl-4-thioxanthen-9-ylidene- CAS REGISTRY NUMBER : 314-03-4 LAST UPDATED : 199707 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C19-H19-N-S MOLECULAR WEIGHT : 293.45 WISWESSER LINE NOTATION : T C666 BS IYJ IU- DT6N DYTJ A1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,62,1972

合成路线

1445-73-4 492-22-8 ~% 314-03-4

文献：FMC CORPORATION Patent: WO2004/26030 A2, 2004 ; Location in patent: Page 31 ;

138248-26-7 ~87% 314-03-4

文献：Honrubia, Maria Angeles; Jesus, Rodriguez; Dominguez, Rosa; Lozoya, Estrella; Manaut, Francesc; Seijas, Julio A.; Villaverde, Maria Carmen; Calleja, Jose M.; Cadavid, Maria Isabel; Maayani, Saul; Sanz, Ferran; Loza, Maria Isabel Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 842 - 848

3967-45-1 ~64% 121360-49-4 314-03-4

文献：Loughhead, David G. Tetrahedron Letters, 1988 , vol. 29, # 45 p. 5701 - 5702

492-22-8 ~% 314-03-4

文献：Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

29976-53-2 ~% 314-03-4

文献：Honrubia, Maria Angeles; Jesus, Rodriguez; Dominguez, Rosa; Lozoya, Estrella; Manaut, Francesc; Seijas, Julio A.; Villaverde, Maria Carmen; Calleja, Jose M.; Cadavid, Maria Isabel; Maayani, Saul; Sanz, Ferran; Loza, Maria Isabel Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 5 p. 842 - 848

3967-45-1 ~% 314-03-4

文献：Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

5570-77-4 ~% 314-03-4

文献：Engelhardt; Zell; Saari; Christy; Colton; Stone; Stavorski; Wenger; Ludden Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 829 - 835

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