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| 中文名 | 丙酸倍氯米松 |
|---|---|
| 英文名 | beclomethasone dipropionate |
| 中文别名 |
丙酸倍氯米松
倍氯米松丙酸酯 倍氯米松二丙酸盐 |
| 英文别名 |
9-Chloro-16-β-methyl-11-β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-Dipropionate
Viarex Beconasol Becloval (11b,16b)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(propanoyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate Becodisks pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11b,16b)- Anceron Vancenase AQ propanoate de (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-triméthyl-3-oxo-17-[(propanoyloxy)acétyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yle (11b,16b)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (11β,16β)- (11β,16β)-9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate EINECS 226-886-0 Beclomethasone dipropionate (USP) Beclomethasone dipropionate Andion MFCD00135613 (8S,9R,10S,11S,13S,14S,16S,17R)-9-Chlor-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[(propanoyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-ylpropanoat 9-Chloro-11b-hydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-Dipropionate Beclometasone dipropionate |
| 描述 | Beclometasone二丙酸盐是糖皮质素激动剂,为beclometasone游离形式的原药。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.3±0.1 g/cm3 |
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| 沸点 | 630.5±55.0 °C at 760 mmHg |
| 熔点 | 210ºC |
| 分子式 | C28H37ClO7 |
| 分子量 | 521.042 |
| 闪点 | 335.1±31.5 °C |
| 精确质量 | 520.222778 |
| PSA | 106.97000 |
| LogP | 4.59 |
| 外观性状 | 白色结晶粉末 |
| 蒸汽压 | 0.0±4.2 mmHg at 25°C |
| 折射率 | 1.564 |
| 储存条件 | 2-8℃ 避光，阴凉干燥处，密封保存 v |
| 稳定性 | 常温常压下稳定，类白色或微黄色结晶性粉 |
| 分子结构 | 1、 摩尔折射率：133.38 2、 摩尔体积（m3/mol）：410.2 3、 等张比容（90.2K）：1099.5 4、 表面张力（dyne/cm）：51.5 5、 极化率（10 -24cm 3）：52.87 |
| 计算化学 | 1、 疏水参数计算参考值（XlogP）：3.1 2、 氢键供体数量：2 3、 氢键受体数量：6 4、 可旋转化学键数量：6 5、 互变异构体数量：8 6、 拓扑分子极性表面积（TPSA）：83.6 7、 重原子数量：26 8、 表面电荷：0 9、 复杂度：516 10、 同位素原子数量：0 11、 确定原子立构中心数量：0 12、 不确定原子立构中心数量：1 13、 确定化学键立构中心数量：0 14、 不确定化学键立构中心数量：0 15、 共价键单元数量：1 |
| 更多 | 1. 性状：未确定 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：未确定 |
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Section 1. Chemical Product and Company Identification Beclomethasone Dipropionate Common Name/ Trade Name Beclomethasone Dipropionate Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
Potential Chronic HealthCARCINOGENIC EFFECTS: Not available. EffectsMUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Classified POSSIBLE for human. DEVELOPMENTAL TOXICITY: Classified Development toxin [POSSIBLE]. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), halogenated compounds. Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onAs with most organic solids, fire is possible at elevated temperatures Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust Hazardsexplosion hazard. Beclomethasone Dipropionate Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe dust. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. It should be stored at 25 deg. C (77 deg. F), but storage at temperatures between 15 and 30 deg. C (59 to 86 deg. F) are acceptable. The product should not be exposed to temperatures above 120 deg. F. because container may burst. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Use a dust respirator is ventilation if inadequate and handling of product creates visible dust clouds. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Solid powder.)OdorOdorless. TasteNot available. 521.1 g/mole Molecular Weight ColorWhite to creamy pH (1% soln/water)Not available. Not available. Boiling Point Melting Point201°C (393.8°F) - 208 C.B^ Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Not available. Ionicity (in Water) Dispersion PropertiesNot available. Very slightly soluble in cold water. Solubility Beclomethasone Dipropionate Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Excess heat Conditions of Instability Not available. Incompatibility with various substances CorrosivityNot available. Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsWARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): >3750 mg/kg [Rat]. Acute toxicity of the dust (LC50): 51.6 mg/m3 2 hours [Rat]. Chronic Effects on Humans Not available. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks on Not available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: Dust may cause eye irritation. Inhalation: A massive single dose is unlikely to cause adverse effects. Dust may cause respiratory tract (nasopharyngeal) irritaiton with nasopharyngitis, nasal burning, rhinorrhea, hoarseness, bronchospasm, coughing and possible nasal septum perforation. It may also cause headache, nausea, vomiting. Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, hypermotility, diarrhea. Other adverse effects of inhalation or ingestion may include: decreased or blurred vision, frequent urination, increased thirst, increased appetite, indegestion, nervousness, convulsions, seizures, muscle contraction or spasticity, trouble sleeping weight gain, dizziness, flushing of the face or cheeks, hiccups, and increased sweating. Chronic Potential Health Effects: Inhalation or Ingestion: Prolonged or repeated inhalation or ingestion may cause possible hypersensitization; acne or other skin problems; hip or shoulder pain; osteoporosis; gradual blurring or loss of vision (cataracts or glaucoma); eye pain or redness; tearing and sensitivity of eyes to light; rounding out of the face; purple lines on arms, face, legs, trunk, groin; unusual increase in hair growth; hypertension; menstrual irregularities; muscle weakness; unusual bruising; rapid weight gain; swelling of feet or lower legs; irregular heartbeat; muscle cramps or pain; unusual tiredness or weakness; impaired wound healing; headache; insomnia; pain in back, ribs, arms or legs; continuing abdominal or stomach pain or burning; nausea; vomiting; bloody or black tarry stools; tendon rupture; thin, fragile skin; blood (changes in erythrocyte and leukocyte count), thymus, and spleen Medical Conditions Aggravated by Exposure: Hypersensitivity to material; ocular herpes simplex; AIDS or HIV infection; heart disease; congestive heart failure; recent heart attack; intestinal anastomoses; strongyloides infestation; diabetes mellitus; mayasthenia gravis; impaired kidney function or disease; esophagitis; gastritis or peptic ulcer; chicken pox or measles (including recent exposure); tuberculosis; system fungal infections. Beclomethasone Dipropionate Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are as toxic as the product itself. Toxicity of the Products of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Not applicable. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Beclomethasone Dipropionate Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. EINECS no. 226-886-0. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)This product is not classified according Not applicable. to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E Beclomethasone Dipropionate WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Beclomethasone Dipropionate All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, SECTION 16 - ADDITIONAL INFORMATION N/A |
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生态学数据: 易燃; 燃烧产生有毒氯化物烟雾
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| 符号 |
GHS08 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H360 |
| 警示性声明 | P201-P308 + P313 |
| 个人防护装备 | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| 危害码 (欧洲) | T:Toxic |
| 风险声明 (欧洲) | R60;R61 |
| 安全声明 (欧洲) | S53-S36/37/39-S45 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | TU3805000 |
| 海关编码 | 2937290090 |
| 海关编码 | 2937290090 |
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