82640-04-8

• 常用中文名：盐酸雷洛昔芬
• 常用英文名：Raloxifene HCl
• CAS号：82640-04-8
• 分子式：C₂₈H₂₈ClNO₄S
• 分子量：510.044
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Estrogen/progestogen Receptor 拮抗剂
• 发布时间：2018-09-19 19:58:53
• 更新时间：2025-08-20 23:59:52
• Raloxifene hydrochloride (LY156758 hydrochloride) 是第二代雌激素受体拮抗剂。

名称

• 中文名: 盐酸雷洛昔芬
• 英文名: raloxifene hydrochloride
• 中文别名: [6-羟基-2-(4-羟苯基)苯并[b]噻酚-3-基]-[4-[2-(1-哌啶基)乙氧基]-苯基]-甲酮盐酸盐; 雷洛西芬中间体
• 英文别名: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanone hydrochloride; [6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(piperidin-1-yl)ethoxy]phenyl}methanone hydrochloride (1:1); Raloxifene HCl; [6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanonhydrochlorid; 1-[2-(4-{[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]carbonyl}phenoxy)ethyl]piperidinium chloride; [6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-piperidinyl)ethoxy]phenyl}methanone hydrochloride (1:1); Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride (1:1); methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride; 6-Hydroxy-2-(p-hydroxyphenyl)benzo(b)thien-3-yl-p-(2-piperidinoethoxy)phenyl ketone hydrochloride; MFCD01938233; Raloxifene hydrochloride; Raloxifene (hydrochloride)

物化性质

• 密度: 1.285g/cm3
• 沸点: 728.2ºC at 760 mmHg
• 熔点: 143-147ºC
• 分子式: C₂₈H₂₈ClNO₄S
• 分子量: 510.044
• 闪点: 394.2ºC
• 精确质量: 509.142761
• PSA: 98.24000
• LogP: 6.81510
• 外观性状: 淡黄色固体
• 折射率: 1.654
• 储存条件: -20°C Freezer
• 水溶解性: DMSO: 28 mg/mL, soluble

生物活性

• 描述: Raloxifene hydrochloride (LY156758 hydrochloride) 是第二代雌激素受体拮抗剂。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 内分泌
• 参考文献:

  [1]. Yang, N.N., et al., Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology, 1996. 137(5): p. 2075-84.

  [2]. Obach, R.S., Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos, 2004. 32(1): p. 89-97.

  [3]. Sato, M., M.K. Rippy, and H.U. Bryant, Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J, 1996. 10(8): p. 905-12.

  [4]. Black, L.J., et al., Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest, 1994. 93(1): p. 63-9.

  [5]. Evans, G., et al., The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology, 1994. 134(5): p. 2283-8.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 22-24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

合成路线

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