147511-69-1

• 常用中文名：匹伐他汀
• 常用英文名：Pitavastatin
• CAS号：147511-69-1
• 分子式：C₂₅H₂₄FNO₄
• 分子量：421.461
• 相关类别： 原料药 循环系统用药 调节血脂药
• 发布时间：2018-07-11 18:07:39
• 更新时间：2026-07-02 17:46:44
• Pitavastatin (NK-104)是HMG-CoA还原酶抑制剂,能抑制从醋酸到胆固醇的合成,IC50为5.8 nM。

名称

• 中文名: 匹伐他汀
• 英文名: pitavastatin
• 中文别名: 氘4-匹伐他汀; Pitavastatin试剂; (3R,5S,6E)-7-(2-环丙基-4-(4-氟苯基)喹啉-3-基)-3,5-二羟基庚-6-烯酸; 匹伐他汀-[D4]/精确称量; 匹伐他汀酸
• 英文别名: Pitavastatin Acid; (3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyht-6-enoic acid; (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-htenoate; Compound T7072; (6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid; PITAVASTATIN; PitavastatinCa; PITVASTATIN; monocalciumbis{(3r,5s,6e)-7-[2-cyclopyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-htenoate}; PITAVASTATIN (NK-104); 6-Htenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (3R,5S,6E); Pitavastatin //BP; PitavastatinQ: What is Pitavastatin Q: What is the CAS Number of Pitavastatin Q: What is the storage condition of Pitavastatin; ITAVASTATIN; Pitavastatin API; MFCD04113054; (3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl)-3,5-dihydroxy-6-htenoic acid; Atorvastatin therapy; 6-Htenoic acid, 7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydroxy-, (S-(R*,S*-(E))); pitavastatin(1-); D4-Pitavastatin

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 692.0±55.0 °C at 760 mmHg
• 分子式: C₂₅H₂₄FNO₄
• 分子量: 421.461
• 闪点: 372.3±31.5 °C
• 精确质量: 421.168945
• PSA: 90.65000
• LogP: 3.45
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.680
• 储存条件: 2-8℃

生物活性

• 描述: Pitavastatin (NK-104)是HMG-CoA还原酶抑制剂,能抑制从醋酸到胆固醇的合成,IC50为5.8 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44.

  [2]. Katsuki S, et al. Nanoparticle-mediated delivery of pitavastatin inhibits atherosclerotic plaque destabilization/rupture in mice by regulating the recruitment of inflammatory monocytes. Circulation. 2014 Feb 25;129(8):896-906.

  [3]. Tajiri K, et al. Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. Cardiovasc Drugs Ther. 2013 Oct;27(5):413-24.

  [4]. Hamano T, et al. Pitavastatin decreases tau levels via the inactivation of Rho/ROCK. Neurobiol Aging. 2012 Oct;33(10):2306-20.

安全

• 危害码 (欧洲): Xi
• 海关编码: 3004909090

海关

海关编码	3004909090