82-98-4

• 常用中文名：哌立度酯
• 常用英文名：Piperidolate
• CAS号：82-98-4
• 分子式：C₂₁H₂₅NO₂
• 分子量：323.429
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 由mAChR
• 发布时间：2018-09-04 10:37:09
• 更新时间：2024-01-07 19:05:43
• Piperidolate是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。

名称

• 中文名: 哌立度酯
• 英文名: (1-ethylpiperidin-3-yl) 2,2-diphenylacetate
• 中文别名: 二苯哌酯; 1-乙基哌啶-3-基2,2-二苯乙酸酯
• 英文别名: Piperidolatum [INN-Latin]; Piperidolato [INN-Spanish]; 1-Ethyl-3-piperidinyl diphenylacetate; Diphenylessigsaeure-(1-aethyl-piperidin-3-yl-ester); Diphenylacetic Acid 1-Ethyl-3-piperidyl Ester; Diphenylessigsaeure-(1-ethyl-piperidin-3-yl-ester); JB 305; diphenylacetic acid-(1-ethyl-[3]piperidyl ester); EINECS 201-449-7; a-Phenylbenzeneacetic Acid 1-Ethyl-3-piperidinyl Ester; Benzeneacetic acid, α-phenyl-, 1-ethyl-3-piperidinyl ester; 1-Ethyl-3-piperidyl diphenylacetate; Piperidolate; 1-Aethyl-3-benzhydrylcarbonyloxy-piperidin; Piperidolate [INN:BAN]; Benzeneacetic acid, α-phenyl-, 1-ethyl-3-piperidinyl ester (9CI); N-Ethyl-3-piperidyl diphenylacetate; Diphenylessigsaeure-(1-aethyl-[3]piperidylester); Dactil

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 431.9±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₅NO₂
• 分子量: 323.429
• 闪点: 136.0±19.6 °C
• 精确质量: 323.188538
• PSA: 29.54000
• LogP: 4.44
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.584
• 储存条件: 2-8°C

生物活性

• 描述: Piperidolate是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AH2900000 CHEMICAL NAME : Acetic acid, diphenyl-, 1-ethyl-3-piperidyl ester CAS REGISTRY NUMBER : 82-98-4 BEILSTEIN REFERENCE NO. : 0031110 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H25-N-O2 MOLECULAR WEIGHT : 323.47 WISWESSER LINE NOTATION : T6NTJ A2 COVYR&R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Cardiac - pulse rate increase, without fall in BP REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,186,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Cardiac - pulse rate increase, without fall in BP REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,186,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intradermal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 59,149,1938 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 16 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Cardiac - pulse rate increase, without fall in BP REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,186,1959

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933399090

合成路线

1871-76-7 ~% 82-98-4

文献：Biel et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 1485,1487

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%