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5086-74-8生产厂家

5086-74-8价格

5086-74-8

5086-74-8结构式
5086-74-8结构式

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中文名 四咪唑 盐酸盐
英文名 Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-phenyl-, hydrochloride (1:1)
中文别名 盐酸四咪唑
英文别名 mcn-jr 8299
levamisole hydrochloride
Tetramisole HCl
(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride
(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
levamisole HCl
(±)-Tetramisole hydrochloride
6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride
orovermol
EINECS 225-799-5
MFCD00005536
6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole hydrochloride (1:1)
McN-JR 8299-11
anthelvet
DL-Tetramisole hydrochloride
citarin
ripereol
bayer9051
r8299
ripercol
Concurat
Tetramisole hydrochloride
l-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride
Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, hydrochloride (1:1)
Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride
nilverm
DL-6-Phenyl-2,3,5,6-tetrahydroimidazole[2,1-b]thiazole Hydrochloride
nilverom
Tetramisole (hydrochloride)
描述 Tetramisole盐酸盐抑制碱性磷酸酶, 是一种高纯度的抗寄生虫。
相关类别
沸点 344.4ºC at 760 mmHg
熔点 266-267ºC
分子式 C11H13ClN2S
分子量 240.752
闪点 162.1ºC
精确质量 240.048798
PSA 40.90000
LogP 2.32160
外观性状 白色至淡奶油色结晶粉末
储存条件

常温,避光,阴凉干燥处,密封保存

稳定性

常温常压下稳定,白色或微黄色针状结晶。无臭。昧苦。溶于水(21g/100ml,20℃)、甲醇、丙二醇,微溶于乙醇、氯仿、己烷和丙酮。有刺激性。

水溶解性 200 g/L (20 ºC)
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积40.9

7.重原子数量:15

8.表面电荷:0

9.复杂度:246

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

更多

1. 性状:白色或微黄色针状结晶。无臭。昧苦

2. 密度(g/mL,25):不确定

3. 相对蒸汽密度(g/mL,空气=1):不确定

4. 熔点(ºC):266-267

5. 沸点(ºC,常压):不确定

6. 沸点(ºC,0.3 mmHg):不确定

7. 折射率(nD20):不确定

8. 闪点(°F):不确定

9. 比旋光度(º, C=1, 水):不确定

10. 自燃点或引燃温度(ºC):不确定

11. 蒸气压(kPa,25ºC):不确定

12. 饱和蒸气压(kPa,60ºC):不确定

13. 燃烧热(KJ/mol):不确定

14. 临界温度(ºC):不确定

15. 临界压力(KPa):不确定

16. 油水(辛醇/水)分配系数的对数值:不确定

17. 爆炸上限(%,V/V):不确定

18. 爆炸下限(%,V/V):不确定

19. 溶解性:溶于水(21g/100ml,20℃)、甲醇、丙二醇,微溶于乙醇、氯仿、己烷和丙酮

Name: Tetramisole hydrochloride 99+% Material Safety Data Sheet
Synonym: DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; (+-)-2,3,5,6-Tetrahycro-6-phenylimidazo (2,1-b)thiazole monohydrochloride; Tatramisole; DL-Tetramisole hydrochloride; Tetramisol hydrochlorid
CAS: 5086-74-8
Section 1 - Chemical Product MSDS Name:Tetramisole hydrochloride 99+% Material Safety Data Sheet
Synonym:DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride; (+-)-2,3,5,6-Tetrahycro-6-phenylimidazo (2,1-b)thiazole monohydrochloride; Tatramisole; DL-Tetramisole hydrochloride; Tetramisol hydrochlorid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
5086-74-8 Tetramisole hydrochloride 99+ 225-799-5
Hazard Symbols: XN
Risk Phrases: 22

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.Toxic.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
Harmful if swallowed. The toxicological properties of this substance have not been fully investigated. Causes gastrointestinal tract irritation.
Inhalation:
The toxicological properties of this substance have not been fully investigated. Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Wash area with soap and water. Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage:
Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 5086-74-8: Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 266.00 - 267.00 deg C
Autoignition Temperature: 500 deg C ( 932.00 deg F)
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 210 g/l (20C)
Specific Gravity/Density: Not available.
Molecular Formula: C11H12N2S.HCl
Molecular Weight: 240.76

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 5086-74-8: NJ5950000 LD50/LC50:
CAS# 5086-74-8: Oral, mouse: LD50 = 210 mg/kg; Oral, rat: LD50 = 480 mg/kg.
Oral, Human: TDLo=2 mg/kg Carcinogenicity:
Tetramisole hydrochloride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
S 28B After contact with skin, wash immediately with
plenty of water and soap.
S 38 In case of insufficient ventilation, wear
suitable respiratory equipment.
WGK (Water Danger/Protection)
CAS# 5086-74-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 5086-74-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 5086-74-8 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1、急性毒性:人体静脉TDLo: 2 mg/kg;大鼠口径LD50:480 mg/kg;大鼠皮下LD50:130mg/kg

大鼠静脉LD50:24 mg/kg;小鼠口径LD50:210 mg/kg;小鼠皮下LD50:84 mg/kg

小鼠静脉LD50:22 mg/kg;鸭口径LD50:22 mg/kg

生态学数据:

该物质对环境可能有危害,对水体应给予特别注意

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5950000
CHEMICAL NAME :
Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (+-)-
CAS REGISTRY NUMBER :
5086-74-8
LAST UPDATED :
199306
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C11-H12-N2-S.Cl-H
MOLECULAR WEIGHT :
240.77
WISWESSER LINE NOTATION :
T55 AN DN FS DUTJ CR &GH -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,602,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
84 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 209,1084,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
958 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
REFERENCE :
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(5),64,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cattle
DOSE/DURATION :
450 mg/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 46,297,1970

符号 GHS07
GHS07
信号词 Warning
危害声明 H302-H315-H319-H335
警示性声明 P261-P305 + P351 + P338
个人防护装备 dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲) Xi:Irritant;
风险声明 (欧洲) R22;R36/37/38
安全声明 (欧洲) S26-S36
危险品运输编码 NONH for all modes of transport
WGK德国 3
RTECS号 NJ5950000
海关编码 2934999090

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5086-74-8结构式

5086-74-8

文献:American Cyanamid Company Patent: US4087611 A1, 1978 ; Title/Abstract Full Text Show Details American Cyanamid Company Patent: US4090025 A1, 1978 ;

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5086-74-8结构式

5086-74-8

文献:American Cyanamid Company Patent: US4090025 A1, 1978 ;

~%

5086-74-8结构式

5086-74-8

文献:DSO "Pharmachim" Patent: US4179460 A1, 1979 ;
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海关编码 2934100090
中文概述 2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%