5003-48-5

• 常用中文名：贝诺酯
• 常用英文名：Benorilate
• CAS号：5003-48-5
• 分子式：C₁₇H₁₅NO₅
• 分子量：313.305
• 相关类别： 原料药 解热镇痛药 解热止痛药
• 发布时间：2018-07-02 23:02:41
• 更新时间：2024-01-02 23:19:23
• Benorilate 是对乙酰氨基酚和乙酰水杨酸的酯化产物,具有抗炎、镇痛、解热的作用。Benorilate还能够抑制前列腺素 (PG) 的合成。

名称

• 中文名: 贝诺酯
• 英文名: 4-Acetamidophenyl 2-acetoxybenzoate
• 中文别名: 普加巴林; 2-乙酰氧基苯甲酸4-乙酰氨基苯酯; 4-乙酰氨基苯; 阿司匹林对乙酰氨基酚酯; 2-乙酰氧基苯甲酸-4-乙酰氨基苯酯
• 英文别名: Fenasprate; 4'-(Acetamido)phenyl-2-acetoxybenzoate; Fenasparate; (1E)-N-{4-[(2-Acetoxybenzoyl)oxy]phenyl}ethanimidic acid; 4-Acetamidophenyl 2-acetoxybenzoate; p-Acetamidophenyl acetylsalicylate; Benzoic acid, 2-(acetyloxy)-, 4-[[(1E)-1-hydroxyethylidene]amino]phenyl ester; Benorilate; EINECS 225-674-5; 4-(acetylamino)phenyl 2-(acetyloxy)benzoate; Benorylate; MFCD00864257; Aspirin acetaminophen ester; (4-acetamidophenyl) 2-acetyloxybenzoate; Benzoic acid, 2-(acetyloxy)-, 4-(acetylamino)phenyl ester; Salicylic Acid Acetate Ester with 4-Hydroxyacetanilide; 4-Acetamidophenyl salicylate acetate; Salipran

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 511.5±60.0 °C at 760 mmHg
• 熔点: 177-181ºC
• 分子式: C₁₇H₁₅NO₅
• 分子量: 313.305
• 闪点: 263.1±32.9 °C
• 精确质量: 313.095032
• PSA: 81.70000
• LogP: 2.22
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.566
• 储存条件: 室温

生物活性

• 描述: Benorilate 是对乙酰氨基酚和乙酰水杨酸的酯化产物,具有抗炎、镇痛、解热的作用。Benorilate还能够抑制前列腺素 (PG) 的合成。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 炎症/免疫
• 靶点:

  Prostaglandin[4].

• 体外研究: Benorilate是一种酯化阿司匹林制剂,其抗风湿特性据报道与阿司匹林一样好[1]。 Benorylate导致肝脏乳酸转化为葡萄糖的大幅度下降,葡萄糖是葡萄糖稳态的重要组成部分。 Benorylate还会损害氨的尿素合成速率,这是肝脏的另一个重要功能[2]。
• 体内研究: Benorylate可能被吸收为完整的分子,这是其良好的胃耐受性[3]。 Benorylate可以抑制实验动物和人体组织中的PG合成[4]。
• 参考文献:

  [1]. Croft DN, et al. Gastric bleeding and benorylate, a new aspirin. Br Med J. 1972 Sep 2;3(5826):545-7.

  [2]. Castell JV, et al. Effects of benorylate and impacina on the metabolism of cultured hepatocytes. Xenobiotica. 1985 Aug-Sep;15(8-9):743-9.

  [3]. Wright V, et al. A review of benorylate - a new antirheumatic drug. Scand J Rheumatol Suppl. 1975;13:5-8.

  [4]. A. Bennett , et al. Inhibition of Prostaglandin Synthesis by Benorylate. Rheumatology, Volume XII, Issue suppl, 1 January 1973, Pages 101-105.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VO0720000 CHEMICAL NAME : Salicylic acid, acetate, ester with 4'-hydroxyacetanilide CAS REGISTRY NUMBER : 5003-48-5 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C17-H15-N-O5 MOLECULAR WEIGHT : 313.33 WISWESSER LINE NOTATION : 1VOR BVOR DMV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - woman DOSE/DURATION : 1280 mg/kg/8D-I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - dehydration REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,1344,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0080609 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1830 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3431293 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1551 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1692,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1255 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3431293 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3960 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 20,143,1980

安全

• 危害码 (欧洲): Xi
• 海关编码: 2924299090

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海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%