184025-18-1

184025-18-1结构式

中文名	环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯
英文名	cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
英文别名	Ciproxifan cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl ketone Methanone, cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]- Cyclopropylpyrrol4-[3-(1H-imidazol-4-yl)propoxy] phenylmorphomethanone Cyclopropyl{4-[3-(1H-imidazol-4-yl)propoxy]phenyl}methanone FUB-359 cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone

描述	Ciproxifan(FUB-359)是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体信号通路 >> 免疫及炎症 >> 组胺受体研究领域 >> 神经疾病
参考文献	[1]. Motawaj M, Arrang JM. Ciproxifan, a histamine H?-receptor antagonist?/?inverse agonist, modulates methamphetamine-induced sensitization in mice. Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x. [2]. Bardgett ME, et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. [3]. Bardgett ME, et al. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502. [4]. Day M, et al. Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochem Pharmacol. 2007 Apr 15;73(8):1123-34. [5]. Pillot C, et al. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14.