69308-37-8

• 常用中文名：(R)-巴氯芬(mM/ml)
• 常用英文名：(R)-Baclofen
• CAS号：69308-37-8
• 分子式：C₁₀H₁₂ClNO₂
• 分子量：213.661
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) GABA Receptor 激动剂
• 发布时间：2018-03-11 08:00:00
• 更新时间：2024-01-01 20:55:57
• (R)-Baclofen(STX209)是选择性GABAB受体激动剂。

名称

• 中文名: (R)-巴氯芬
• 英文名: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
• 中文别名: (R)-4-氨基-3-(4-氯苯基)丁酸
• 英文别名: (R)-(-)-Baclofen; (βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid; Z1YR DG&1VQ &&(R)-(-)- Form; (-)-Baclofen; Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)-; (R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid; (3R)-4-Amino-3-(4-chlorophenyl)butyric acid; (3R)-4-Amino-3-(4-chlorophenyl)butanoic acid; (R)-Baclofen; (R)-4-Amino-3-(4-chlorophenyl)butanoic acid; Arbaclofen; MFCD01321057; (R)-(-)-4-Amino-3-(4-chlorophenyl)butyric acid

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 364.3±32.0 °C at 760 mmHg
• 熔点: 171-174°C
• 分子式: C₁₀H₁₂ClNO₂
• 分子量: 213.661
• 闪点: 174.1±25.1 °C
• 精确质量: 213.055649
• PSA: 63.32000
• LogP: 1.56
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.577
• 储存条件: Store at RT

生物活性

• 描述: (R)-Baclofen(STX209)是选择性GABAB受体激动剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.

  [2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.

  [3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.

  [4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

  [5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

MSDS

Name: (R)-(-)-Baclofen Material Safety Data Sheet Synonym: CAS: 69308-37-8 Section 1 - Chemical Product MSDS Name:(R)-(-)-Baclofen Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 69308-37-8 (R)-(-)-Baclofen unlisted Hazard Symbols: T Risk Phrases: 25 36/37/38 42/43 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Toxic if swallowed. Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation and skin contact. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Ingestion: Poison by ingestion. Inhalation: Causes respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid immediately. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Substance is noncombustible. Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 69308-37-8: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Not available. Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: ClC6H4CH(CH2NH2)CH2COOH Molecular Weight: 213.66 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 69308-37-8 unlisted. LD50/LC50: Not available. Carcinogenicity: (R)-(-)-Baclofen - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.* Hazard Class: 6.1 UN Number: 2811 Packing Group: III IMO Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing Group: III RID/ADR Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T Risk Phrases: R 25 Toxic if swallowed. R 36/37/38 Irritating to eyes, respiratory system and skin. R 42/43 May cause sensitization by inhalation and skin contact. Safety Phrases: S 22 Do not breathe dust. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 28A After contact with skin, wash immediately with plenty of water. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 69308-37-8: No information available. Canada CAS# 69308-37-8 is listed on Canada's DSL List. CAS# 69308-37-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 69308-37-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

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