(R)-巴氯芬(mM/ml)

• 常用名: (R)-巴氯芬(mM/ml)
• 英文名: (R)-Baclofen
• CAS号: 69308-37-8
• 分子量: 213.661
• 密度: 1.3±0.1 g/cm3
• 沸点: 364.3±32.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂ClNO₂
• 熔点: 171-174°C
• 闪点: 174.1±25.1 °C

(R)-巴氯芬(mM/ml)用途

(R)-Baclofen(STX209)是选择性GABAB受体激动剂。

(R)-巴氯芬(mM/ml)名称

• 中文名: (R)-巴氯芬
• 英文名: (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
• 中文别名: (R)-4-氨基-3-(4-氯苯基)丁酸

(R)-巴氯芬(mM/ml)生物活性

• 描述: (R)-Baclofen(STX209)是选择性GABAB受体激动剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Falch E, Hedegaard A, Nielsen L et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47(3):898-903.

  [2]. Hong YG, Henry JL. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196(3):267-75.

  [3]. Orsnes G, Crone C, Krarup C et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111(8):1372-9.

  [4]. Colombo G, Addolorato G, Agabio R et al. Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res. 2004;6(5):403-14.

  [5]. Stetkarova I, Yablon SA, Kofler M, Stokic DS. Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabil Neural Repair. 2010 Sep;24(7):609-19.

(R)-巴氯芬(mM/ml)物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 364.3±32.0 °C at 760 mmHg
• 熔点: 171-174°C
• 分子式: C₁₀H₁₂ClNO₂
• 分子量: 213.661
• 闪点: 174.1±25.1 °C
• 精确质量: 213.055649
• PSA: 63.32000
• LogP: 1.56
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.577
• 储存条件: Store at RT

(R)-巴氯芬(mM/ml)MSDS

(R)-巴氯芬(mM/ml)MSDS英文版

(R)-巴氯芬(mM/ml)英文别名

• (R)-(-)-Baclofen
• (βR)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
• Z1YR DG&1VQ &&(R)-(-)- Form
• (-)-Baclofen
• Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, (βR)-
• (R)-(-)-4-Amino-3-(4-chlorophenyl)butanoic acid
• (3R)-4-Amino-3-(4-chlorophenyl)butyric acid
• (3R)-4-Amino-3-(4-chlorophenyl)butanoic acid
• (R)-Baclofen
• (R)-4-Amino-3-(4-chlorophenyl)butanoic acid
• Arbaclofen
• MFCD01321057
• (R)-(-)-4-Amino-3-(4-chlorophenyl)butyric acid