1200133-34-1

• 常用中文名：5-(1-环己烯-1-基)-3-[(反式-4-甲氧基环己基)[( 反式-4-甲基环己基)羰基]氨基]噻吩-2-羧酸钾盐
• 常用英文名：VCH-916
• CAS号：1200133-34-1
• 分子式：C₂₆H₃₆KNO₄S
• 分子量：497.732
• 相关类别： 信号通路 抗感染 HCV
• 发布时间：2018-12-28 00:53:53
• 更新时间：2024-01-14 11:08:12
• VCH-916是非核苷类HCV NS5B聚合酶抑制剂。

名称

• 中文名: 5-(1-环己烯-1-基)-3-[(反式-4-甲氧基环己基)[( 反式-4-甲基环己基)羰基]氨基]噻吩-2-羧酸钾盐
• 英文名: potassium,5-(cyclohexen-1-yl)-3-[(4-methoxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylate
• 英文别名: S1493_Selleck; CS-1224; Potassium 5-(1-cyclohexen-1-yl)-3-{(trans-4-methoxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-2-thiophenecarboxylate; VCH 916; 2-Thiophenecarboxylic acid, 5-(1-cyclohexen-1-yl)-3-[(trans-4-methoxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-, potassium salt (1:1); VCH-916||VCH 916; VCH-916

物化性质

• 分子式: C₂₆H₃₆KNO₄S
• 分子量: 497.732
• 精确质量: 497.200226
• PSA: 97.91000
• LogP: 5.18590
• 储存条件: 2-8℃

生物活性

• 描述: VCH-916是非核苷类HCV NS5B聚合酶抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HCV蛋白酶
  信号通路 >> 抗感染 >> HCV
  研究领域 >> 感染
• 参考文献:

  [1]. Ludmila Gerber, Tania M. Welzel, Stefan Zeuzem. New therapeutic strategies in HCV: polymerase inhibitors. Liver International. 2013,33(s1): 85-92

  [2]. Abdelrahman S. Mayhoub. Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and resistance relationships; different scaffolds and mutations. Bioorganic & Medicinal Chemistry. 2012, 20 (10): 3150-3161.

  [3]. Debasis Dasa, Jian Honga, Shu-Hui Chena, et al. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4690-4703

  [4]. Pierre L Beaulieu. Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Informahealthcare. 2009, 19(2): 145-164

  [5]. Safety,Tolerability and Pharmacokinetics of Multiple Ascending Doses of VCH 916 in Subjects With Chronic Hep C Infection