992-21-2

992-21-2结构式
992-21-2结构式

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中文名 赖甲环素
英文名 lymecycline
中文别名 四环素亚甲赖氨酸
英文别名 limecycline
[(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2r,3s)-2,3-dihydroxy-2-isopropylbutanoate
2,3-Dihydroxy-2-(1-methylethyl)-butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester
lycopsamine
(+)-Indicine
描述 Lymecycline 是四环素衍生物,具有广谱的抗菌活性,同时具有抗炎活性。
相关类别
靶点

Bacterial[1]

体外研究 利美环素是一种四环素衍生物,具有广谱抗菌活性,可干扰核糖体水平的原核蛋白合成。利美环素还具有抗炎特性[1]。
参考文献

[1]. Rempe S, et al. Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6.  

密度 1.53
沸点 840.5ºC at 760 mmHg
熔点 192.5°C
分子式 C29H38N4O10
分子量 602.63
闪点 462.1ºC
精确质量 602.25900
PSA 242.98000
LogP 1.02790
折射率 1.693
水溶解性 Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL5615000
CHEMICAL NAME :
Lysine, N(sup 6)-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxa mido)methyl)-, (+)-
CAS REGISTRY NUMBER :
992-21-2
LAST UPDATED :
199201
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C29-H38-N4-O10
MOLECULAR WEIGHT :
602.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
181 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,333,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
253 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,106,1964