53808-87-0

• 常用中文名：四氧普林
• 常用英文名：Tetroxoprim
• CAS号：53808-87-0
• 分子式：C₁₆H₂₂N₄O₄
• 分子量：334.37
• 相关类别： 信号通路 细胞周期/DNA损伤 叶酸
• 发布时间：2018-02-19 08:00:00
• 更新时间：2024-01-07 15:46:26
• 四氢呋喃是一种抗菌DHFR抑制剂[1]。

名称

• 中文名: 四氧普林
• 英文名: 5-[[3,5-dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]pyrimidine-2,4-diamine
• 中文别名: 5-(3,5-二甲氧基-4-(2-甲氧基乙氧基)苄基)嘧啶-2,4-二胺
• 英文别名: Tetroxoprima; Tetroxoprime [INN-French]; Tetroxoprimum [INN-Latin]; Tetroxoprime; Tetroxoprim; Tetroxoprimum; He 781; Tetroxoprima [INN-Spanish]; Tetroxoprima [Spanish]

物化性质

• 密度: 1.232g/cm3
• 沸点: 564.1ºC at 760mmHg
• 分子式: C₁₆H₂₂N₄O₄
• 分子量: 334.37
• 闪点: 294.9ºC
• 精确质量: 334.16400
• PSA: 114.74000
• LogP: 2.43660
• 折射率: 1.587
• 储存条件: 2-8°C，避光，干燥，密封

生物活性

• 描述: 四氢呋喃是一种抗菌DHFR抑制剂[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> 叶酸
  研究领域 >> 炎症/免疫
• 体外研究: 在浓度为4 x 10-9M的大肠杆菌中,四氢呋喃可产生50%的体外抑制作用[1]。
• 参考文献:

  [1]. H S Aschhoff, et al. Tetroxoprim--a new inhibitor of bacterial dihydrofolate reductase. J Antimicrob Chemother. 1979 Nov;5(B):19-25.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV8190000 CHEMICAL NAME : Pyrimidine, 2,4-diamino-5-(3,5-dimethoxy-4-(2-methoxyethoxy)benzy l)- CAS REGISTRY NUMBER : 53808-87-0 BEILSTEIN REFERENCE NO. : 4271695 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C16-H22-N4-O4 MOLECULAR WEIGHT : 334.42 WISWESSER LINE NOTATION : T6N CNJ BZ DZ E1R CO1 EO1 DO2O1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1172 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,895,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,895,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1060 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1410 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 192 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,895,1979

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933599090

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%