5231-60-7

• 常用中文名：温都罗新
• 常用英文名：vindorosine
• CAS号：5231-60-7
• 分子式：C₂₄H₃₀N₂O₅
• 分子量：426.51
• 相关类别： 天然产物 生物碱
• 发布时间：2018-06-28 13:05:26
• 更新时间：2024-01-06 12:49:37
• 长春花苷是毛叶长春花中的一种生物碱。Vindorosine可放松肾动脉[1][2]。

名称

• 中文名: 温都罗新
• 英文名: 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro-4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate
• 中文别名: 长春尼定; 文朵尼定碱
• 英文别名: methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; Demethoxyvindoline; Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; vindorosine; Vindorosin; Vindolidine; Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-; Vindolidin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 532.8±50.0 °C at 760 mmHg
• 熔点: 167°
• 分子式: C₂₄H₃₀N₂O₅
• 分子量: 426.51
• 闪点: 276.0±30.1 °C
• 精确质量: 426.215485
• PSA: 79.31000
• LogP: 2.30
• 外观性状: 粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.635
• 储存条件: 2-8℃，干燥，密闭

生物活性

• 描述: 长春花苷是毛叶长春花中的一种生物碱。Vindorosine可放松肾动脉[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Cordell GA, et al. Catharanthus alkaloids XXXII: isolation of alkaloids from Catharanthus trichophyllus roots and structure elucidation of cathaphylline. J Pharm Sci. 1976 Mar;65(3):366-9.

  [2]. Wu XL, et al. Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus-derived vindorosine in rat renal artery. Planta Med. 2014 Dec;80(18):1672-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NM2410000 CHEMICAL NAME : 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro- 4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate CAS REGISTRY NUMBER : 5231-60-7 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C24-H30-N2-O5 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04195

安全

• 危害码 (欧洲): Xi