Shanghai Nianxing Industrial Co., Ltd
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Product Name: vindorosine
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BioBioPha
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Product Name: Vindorosine
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Shanghai Jizhi Biochemical Technology Co., Ltd
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Product Name: vindorosine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Demethoxyvindoline
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5231-60-7

5231-60-7 structure

5231-60-7 structure

Name: vindorosine
Chemical Name: 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro-4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate
CAS Number: 5231-60-7
Molecular Formula: C₂₄H₃₀N₂O₅
Molecular Weight: 426.51
Catalog: Natural product Alkaloid
Create Date: 2018-06-28 13:05:26
Modify Date: 2024-01-06 12:49:37
Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries[1][2].

Name	1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro-4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate
Synonyms	methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate Demethoxyvindoline Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate vindorosine Vindorosin Vindolidine Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)- Vindolidin

Description	Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Cordell GA, et al. Catharanthus alkaloids XXXII: isolation of alkaloids from Catharanthus trichophyllus roots and structure elucidation of cathaphylline. J Pharm Sci. 1976 Mar;65(3):366-9. [2]. Wu XL, et al. Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus-derived vindorosine in rat renal artery. Planta Med. 2014 Dec;80(18):1672-7.

Density	1.3±0.1 g/cm3
Boiling Point	532.8±50.0 °C at 760 mmHg
Melting Point	167°
Molecular Formula	C₂₄H₃₀N₂O₅
Molecular Weight	426.51
Flash Point	276.0±30.1 °C
Exact Mass	426.215485
PSA	79.31000
LogP	2.30
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.635

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2410000

CHEMICAL NAME :: 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro- 4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate

CAS REGISTRY NUMBER :: 5231-60-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H30-N2-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04195

Hazard Codes	Xi

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