vindorosine

Modify Date: 2025-08-25 18:02:10

vindorosine structure	Common Name	vindorosine
	CAS Number	5231-60-7	Molecular Weight	426.51
	Density	1.3±0.1 g/cm3	Boiling Point	532.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₃₀N₂O₅	Melting Point	167°
	MSDS	N/A	Flash Point	276.0±30.1 °C

Use of vindorosine

Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries[1][2].

Name	1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro-4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate
Synonym	More Synonyms

Description	Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Cordell GA, et al. Catharanthus alkaloids XXXII: isolation of alkaloids from Catharanthus trichophyllus roots and structure elucidation of cathaphylline. J Pharm Sci. 1976 Mar;65(3):366-9. [2]. Wu XL, et al. Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus-derived vindorosine in rat renal artery. Planta Med. 2014 Dec;80(18):1672-7.

Description

Vindorosine is an alkaloid from Catharanthus trichophyllus Roots. Vindorosine relaxes renal arteries[1][2].

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

References

[1]. Cordell GA, et al. Catharanthus alkaloids XXXII: isolation of alkaloids from Catharanthus trichophyllus roots and structure elucidation of cathaphylline. J Pharm Sci. 1976 Mar;65(3):366-9.

[2]. Wu XL, et al. Antagonism of Ca2+ influx via L-type Ca2+ channels mediates the vasorelaxant effect of Catharanthus roseus-derived vindorosine in rat renal artery. Planta Med. 2014 Dec;80(18):1672-7.

Density	1.3±0.1 g/cm3
Boiling Point	532.8±50.0 °C at 760 mmHg
Melting Point	167°
Molecular Formula	C₂₄H₃₀N₂O₅
Molecular Weight	426.51
Flash Point	276.0±30.1 °C
Exact Mass	426.215485
PSA	79.31000
LogP	2.30
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.635

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2410000

CHEMICAL NAME :: 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 3a-ethyl-3a,4,5,5a,6,11,12,13a-octahydro- 4,5-dihydroxy-6-methyl-, methyl ester, 4-acetate

CAS REGISTRY NUMBER :: 5231-60-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H30-N2-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04195

Hazard Codes	Xi

methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate

Demethoxyvindoline

Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-3-hydroxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate

vindorosine

Vindorosin

Vindolidine

Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-

Vindolidin

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China
Product Name: Demethoxyvindoline
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vindorosine

Use of vindorosine

Names

vindorosine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.