74298-63-8

• 常用中文名：1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐
• 常用英文名：Chlormidazole hydrochloride
• CAS号：74298-63-8
• 分子式：C₁₅H₁₄Cl₂N₂
• 分子量：293.19100
• 相关类别： 信号通路 抗感染 真菌
• 发布时间：2019-01-14 16:56:10
• 更新时间：2024-01-08 09:19:52
• Chlormidazole hydrochloride 是一种抗真菌剂 ( antifungal agent),对多种真菌和部分革兰氏阳性球菌有抑制活性。Chlormidazole hydrochloride 可用于指甲和皮肤的真菌和细菌感染,包括指间和甲周真菌。

名称

• 中文名: 1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐
• 英文名: 3-(4-Chlorobenzyl)-2-methyl-1H-benzimidazol-3-ium chloride
• 英文别名: chloromethyl-trimethyl stannane; Trimethyl-chlormethyl-stannan; Chlorimidazole hydrochloride; Chlormethyl-trimethyl-zinn; Chlormethyl-trimethyl-stannan; chlormidazole hydrochloride; chloromethyl-trimethyl tin; Chlormethylen-trimethylzinn

物化性质

• 沸点: 467.5ºC at 760 mmHg
• 分子式: C₁₅H₁₄Cl₂N₂
• 分子量: 293.19100
• 闪点: 236.5ºC
• 精确质量: 292.05300
• PSA: 17.82000
• LogP: 4.84840
• 外观性状: 固体
• 储存条件: -20°C

生物活性

• 描述: Chlormidazole hydrochloride 是一种抗真菌剂 ( antifungal agent),对多种真菌和部分革兰氏阳性球菌有抑制活性。Chlormidazole hydrochloride 可用于指甲和皮肤的真菌和细菌感染,包括指间和甲周真菌。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 靶点:

  IC50: fungal[1]

• 参考文献:

  [1]. Daniel J. Sheehan, et al. Current and Emerging Azole Antifungal Agents. Clin Microbiol Rev. 1999 Jan; 12(1): 40–79.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DD6700000 CHEMICAL NAME : Benzimidazole, 1-(p-chlorobenzyl)-2-methyl-, hydrochloride CAS REGISTRY NUMBER : 74298-63-8 LAST UPDATED : 199112 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C15-H13-Cl-N2.Cl-H MOLECULAR WEIGHT : 293.21 WISWESSER LINE NOTATION : T56 BN DNJ B1R DG& C1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 58 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

安全

• 危害码 (欧洲): Xi