Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(4-CHLORO-BENZENESULFONYL)-PYRROLIDINE-2-CARBOXYLICACID
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Purity: 98.0%
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74298-63-8

74298-63-8 structure

Name: Chlormidazole hydrochloride
Chemical Name: 3-(4-Chlorobenzyl)-2-methyl-1H-benzimidazol-3-ium chloride
CAS Number: 74298-63-8
Molecular Formula: C₁₅H₁₄Cl₂N₂
Molecular Weight: 293.19100
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2019-01-14 16:56:10
Modify Date: 2024-01-08 09:19:52
Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses[1].

Name	3-(4-Chlorobenzyl)-2-methyl-1H-benzimidazol-3-ium chloride
Synonyms	chloromethyl-trimethyl stannane Trimethyl-chlormethyl-stannan Chlorimidazole hydrochloride Chlormethyl-trimethyl-zinn Chlormethyl-trimethyl-stannan chlormidazole hydrochloride chloromethyl-trimethyl tin Chlormethylen-trimethylzinn

Description	Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
Target	IC50: fungal[1]
References	[1]. Daniel J. Sheehan, et al. Current and Emerging Azole Antifungal Agents. Clin Microbiol Rev. 1999 Jan; 12(1): 40–79.

Boiling Point	467.5ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄Cl₂N₂
Molecular Weight	293.19100
Flash Point	236.5ºC
Exact Mass	292.05300
PSA	17.82000
LogP	4.84840
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6700000

CHEMICAL NAME :: Benzimidazole, 1-(p-chlorobenzyl)-2-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 74298-63-8

LAST UPDATED :: 199112

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H13-Cl-N2.Cl-H

MOLECULAR WEIGHT :: 293.21

WISWESSER LINE NOTATION :: T56 BN DNJ B1R DG& C1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

Hazard Codes	Xi

54118-67-1	74298-63-8
1406-14-0	6138-79-0
127228-87-9	143851-98-3
929-73-7	65546-09-0
1135280-78-2	56-99-5