Chlormidazole hydrochloride

Modify Date: 2024-01-08 09:19:52

Chlormidazole hydrochloride Structure
Chlormidazole hydrochloride structure
Common Name Chlormidazole hydrochloride
CAS Number 74298-63-8 Molecular Weight 293.19100
Density N/A Boiling Point 467.5ºC at 760 mmHg
Molecular Formula C15H14Cl2N2 Melting Point N/A
MSDS N/A Flash Point 236.5ºC

 Use of Chlormidazole hydrochloride


Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses[1].

 Names

Name 3-(4-Chlorobenzyl)-2-methyl-1H-benzimidazol-3-ium chloride
Synonym More Synonyms

 Chlormidazole hydrochloride Biological Activity

Description Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses[1].
Related Catalog
Target

IC50: fungal[1]

References

[1]. Daniel J. Sheehan, et al. Current and Emerging Azole Antifungal Agents. Clin Microbiol Rev. 1999 Jan; 12(1): 40–79.

 Chemical & Physical Properties

Boiling Point 467.5ºC at 760 mmHg
Molecular Formula C15H14Cl2N2
Molecular Weight 293.19100
Flash Point 236.5ºC
Exact Mass 292.05300
PSA 17.82000
LogP 4.84840
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6700000
CHEMICAL NAME :
Benzimidazole, 1-(p-chlorobenzyl)-2-methyl-, hydrochloride
CAS REGISTRY NUMBER :
74298-63-8
LAST UPDATED :
199112
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C15-H13-Cl-N2.Cl-H
MOLECULAR WEIGHT :
293.21
WISWESSER LINE NOTATION :
T56 BN DNJ B1R DG& C1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
58 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

 Safety Information

Hazard Codes Xi

 Synonyms

chloromethyl-trimethyl stannane
Trimethyl-chlormethyl-stannan
Chlorimidazole hydrochloride
Chlormethyl-trimethyl-zinn
Chlormethyl-trimethyl-stannan
chlormidazole hydrochloride
chloromethyl-trimethyl tin
Chlormethylen-trimethylzinn