中文名 | Oprozomib |
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英文名 | N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide |
英文别名 |
ONX-0912
4,5-Anhydro-1,2-dideoxy-4-methyl-2-({O-methyl-N-[(2-methyl-1,3-thiazol-5-yl)carbonyl]-L-seryl-O-methyl-L-seryl}amino)-1-phenyl-D-erythro-pent-3-ulose QC-9273 PR-047 ONX 0912 D-erythro-3-Pentulose, 4,5-anhydro-1,2-dideoxy-4-C-methyl-2-[[O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-L-seryl]amino]-1-phenyl- |
描述 | Oprozomib (ONX 0912; PR047)是口服生物相容性的抑制剂,能抑制20S proteasome(20S蛋白酶体)β5/LMP7的CT-L活性,IC50为36 nM/82 nM。 |
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参考文献 |
密度 | 1.3±0.1 g/cm3 |
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沸点 | 849.9±65.0 °C at 760 mmHg |
分子式 | C25H32N4O7S |
分子量 | 532.609 |
闪点 | 467.8±34.3 °C |
精确质量 | 532.199158 |
PSA | 186.96000 |
LogP | 2.79 |
外观性状 | 粉末 |
蒸汽压 | 0.0±3.2 mmHg at 25°C |
折射率 | 1.573 |
储存条件 | -20℃ |
~86% 935888-69-0 |
文献:Jumaa, Mouhannad; Muchamuel, Tony; Bejugam, Naveen; Wong, Hansen; Kirk, Christopher J.; Vishram Manek, Rahul; Sharma, Sanjeev Patent: US2014/113855 A1, 2014 ; Location in patent: Paragraph 0279; 0305; 0306; 0307; 0308 ; |
~% 935888-69-0 |
文献:Zhou, Han-Jie; Aujay, Monette A.; Bennett, Mark K.; Dajee, Maya; Demo, Susan D.; Fang, Ying; Ho, Mark N.; Jiang, Jing; Kirk, Christopher J.; Laidig, Guy J.; Lewis, Evan R.; Lu, Yan; Muchamuel, Tony; Parlati, Francesco; Ring, Eileen; Shenk, Kevin D.; Shields, Jamie; Shwonek, Peter J.; Stanton, Timothy; Sun, Congcong M.; Sylvain, Catherine; Woo, Tina M.; Yang, Jinfu Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 3028 - 3038 |
~% 935888-69-0 |
文献:US2014/113855 A1, ; |
~% 935888-69-0 |
文献:US2014/113855 A1, ; |
~% 935888-69-0 |
文献:US2014/113855 A1, ; |
~% 935888-69-0 |
文献:US2014/113855 A1, ; |
~% 935888-69-0 |
文献:US2014/113855 A1, ; |
上游产品 4 | |
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下游产品 0 |