8006-39-1

• 常用中文名：松脂醇
• 常用英文名：terpineols
• CAS号：8006-39-1
• 分子式：C₁₀H₁₈O
• 分子量：154.24900
• 相关类别： 香精与香料 合成香料 醇类香料 萜烯醇
• 发布时间：2018-06-19 18:30:06
• 更新时间：2024-01-06 15:13:54
• 　　松油醇是我国规定允许使用的食用香料，主要用于柠檬、甜橙、草莓、桃等水果香精中。用量按正常生产需要，一般在口香糖中40mg/kg；调味料中38mg/kg；烘烤食品中19mg/kg;冷饮中16mg/kg；糖果中14mg/kg；布丁类中12~16mg/kg软饮料中5.4mg/kg。
   　　GB 2760--1996规定为允许使用的食用香料。主要用以配制柠檬、白柠檬等柑橘类水果以及桃子、樱桃、树莓等香精。

名称

• 中文名: 松脂醇
• 英文名: terpineol
• 中文别名: 松油醇(异构体混合物); 松油醇

物化性质

• 密度: 0.937
• 沸点: 214-224ºC
• 熔点: 18ºC
• 分子式: C₁₀H₁₈O
• 分子量: 154.24900
• 闪点: 95ºC
• 精确质量: 154.13600
• PSA: 20.23000
• LogP: 2.50370
• 外观性状: 略粘性透明液体
• 折射率: n20/D 1.484
• 储存条件: 库房通风低温干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.8

  2.氢键供体数量:1

  3.氢键受体数量:1

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积20.2

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:168

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色稠厚液体，具有紫丁香花的香气

  2. 密度（g/mL 25ºC）：0.934

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC常压）：未确定

  5. 沸点（ºC，常压）：213-218

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率（n20/D）：1.484

  8. 闪点（ºC，）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性(mg/mL) ：易溶于乙醇、丙酮、氯仿、乙醚和苯等有机溶剂，不溶于水

MSDS

Name: Terpineol Material Safety Data Sheet Synonym: 3-cyclohexene-1-methanol; terpeno CAS: 8006-39-1 Section 1 - Chemical Product MSDS Name:Terpineol Material Safety Data Sheet Synonym:3-cyclohexene-1-methanol; terpeno Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 8006-39-1 Terpineol 100 232-268-1 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Inhalation: May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Keep container closed when not in use. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels. Exposure Limits CAS# 8006-39-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: off-white Odor: Not available. pH: Not available. Vapor Pressure: 0.1 mm Hg @ 37.7C Viscosity: Not available. Boiling Point: 214-224C Freezing/Melting Point: 31-35C Autoignition Temperature: Not applicable. Flash Point: 193 deg F ( 89.44 deg C) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Very sightly soluble in water Specific Gravity/Density: 0.93 Molecular Formula: C10H18O Molecular Weight: 154.1254 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Excess heat. Incompatibilities with Other Materials: Strong oxidizing agents, acid chlorides, acid anhydrides. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 8006-39-1: WZ6600000 LD50/LC50: CAS# 8006-39-1: Draize test, rabbit, skin: 500 mg/24H Moderate; Oral, rat: LD50 = 4300 mg/kg. Carcinogenicity: Terpineol - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Shipping Name: Not regulated. Hazard Class: UN Number: Packing group: Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 8006-39-1: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 8006-39-1 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 8006-39-1 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性：人经口LD503～4g/kg，大白鼠经口LD504.3g/kg，ADI1mg/kg(CE)。 CHEMICAL IDENTIFICATION RTECS NUMBER : WZ6600000 CHEMICAL NAME : Terpineol CAS REGISTRY NUMBER : 8006-39-1 LAST UPDATED : 199504 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H18-O MOLECULAR WEIGHT : 154.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,997,1974 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,997,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1360 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952- Volume(issue)/page/year: 3,73,1952 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0240 No. of Facilities: 287 (estimated) No. of Industries: 4 No. of Occupations: 4 No. of Employees: 1050 (estimated) No. of Female Employees: 42 (estimated)

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R38
• 安全声明 (欧洲): 26
• WGK德国: 1
• RTECS号: WZ6600000

制备

松油醇天然存在于松节油、香叶油、松针油等，工业上以松节油或异戊二烯为原料制备。
硫酸催化两步法：在30%舶硫酸作用下松节油中的蒎烯生成水合萜二醇结晶沉淀，分离后在0.2%的硫酸催化下脱水生成松油醇，分层分离得粗醇，经减压蒸馏得成品。
如采用相转移催化法，则效果更好。将33g松节油、50g80%的硫酸、0.lg三乙基苄基氯化铵(TEBA)和1mL10%的平平加水溶液加入烧瓶，在12~14℃下快速搅拌反应12h。得白色粉末状萜二醇25.6g，产率58.7%。
将24g萜二醇、48mL0.2%的硫酸加入烧瓶，在102～105℃下搅拌反应4～5h。静置除去水层，油层用3%的氢氧化钠溶液中和、静置、分层得18.2g黄色油状液体。减压蒸馏，收集190~200℃(90kPa)馏分，得精品15.5g，收率73%。
异戊二烯与丁烯酮缩合，然后与格氏试剂反应制得松油醇。
磷酸催化一步法：75mL的松节油(含β-蒎烯91%)和75mL 30%磷酸水溶液，在70℃下强烈搅拌反应16h。反应液冷却静置，分出水层，油层用稀NaOH水溶液中和至中性，分去水层，再用少量食盐水洗涤，最后经无水硫酸钠干燥后减压蒸馏得成品。