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1,1'-二乙基-2,2'-碘化氰

1,1'-二乙基-2,2'-碘化氰用途

伪异氰(碘)是具有抗抑郁活性的单胺转运体和有机阳离子转运体的pan抑制剂。

1,1'-二乙基-2,2'-碘化氰名称

[ CAS 号 ]:
977-96-8

[ 中文名 ]:
1,1'-二乙基-2,2'-碘化氰

[ 英文名 ]:
1,1'-Diethyl-2,2'-cyanine iodide

[中文别名 ]:

[英文别名 ]:

1,1'-DIETHYL-2,2'-CYANINE IODIDE
EINECS 213-556-6
MFCD00011971

1,1'-二乙基-2,2'-碘化氰生物活性

[ 描述 ]:

伪异氰(碘)是具有抗抑郁活性的单胺转运体和有机阳离子转运体的pan抑制剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 多巴胺转运蛋白

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

信号通路 >> 跨膜转运 >> 单胺转运蛋白

[参考文献]

[1]. Fraser-Spears R, et al. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. Eur J Pharmacol. 2019 Jan 5;842:351-364.

1,1'-二乙基-2,2'-碘化氰物理化学性质

[ 熔点 ]:
273ºC

[ 分子式 ]:
C₂₃H₂₃IN₂

[ 分子量 ]:
454.34700

[ 精确质量 ]:
454.09100

[ PSA ]:
8.81000

[ LogP ]:
1.23570

[ 外观性状 ]:
暗红色晶体

[ 储存条件 ]:
避免光

1,1'-二乙基-2,2'-碘化氰MSDS

1,1'-二乙基-2,2'-碘化氰安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H330-H312-H315-H319-H335

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
45

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

1,1'-二乙基-2,2'-碘化氰合成路线

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1,1'-二乙基-2,2'-碘化氰文献

Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression.

J. Neurosci. 33(25) , 10534-43, (2013)

Mood disorders cause much suffering and lost productivity worldwide, compounded by the fact that many patients are not effectively treated by currently available medications. The most commonly prescri...

Involvement of the organic cation transporters in histamine uptake into human vascular endothelial cells.

Inflamm. Res. 58 Suppl 1 , 61-2, (2009)

Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus.

Brain Res. 1063(1) , 69-76, (2005)

In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not ...

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