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氟茚二酮

氟茚二酮用途

Fluindione 是 5-lipoxygenase 的抑制剂,IC50 为 15 μM。Fluindione 具有抗炎活性。

氟茚二酮名称

[ CAS 号 ]:
957-56-2

[ 中文名 ]:
氟茚二酮

[ 英文名 ]:
Fluindione

[英文别名 ]:

2-(4-Fluor-phenyl)-indandion-(1,3)
1H-Indene-1,3(2H)-dione,2-(4-fluorophenyl)
Fluindione
Fluindionum [INN-Latin]
Fluindione [INN]
2-(4-fluoro-phenyl)-indan-1,3-dione
2-(p-Fluorophenyl)-1,3-indandione
Previscan
Fluindiona [INN-Spanish]
LM 123

氟茚二酮生物活性

[ 描述 ]:

Fluindione 是 5-lipoxygenase 的抑制剂,IC50 为 15 μM。Fluindione 具有抗炎活性。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. Brooks, et al. Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenase. Bioorganic & Medicinal Chemistry Letters, 2(10), 1309–1314.

氟茚二酮物理化学性质

[ 密度 ]:
1.335g/cm3

[ 沸点 ]:
406.3ºC at 760mmHg

[ 分子式 ]:
C₁₅H₉FO₂

[ 分子量 ]:
240.23

[ 闪点 ]:
154.5ºC

[ 精确质量 ]:
240.05900

[ PSA ]:
34.14000

[ LogP ]:
2.98850

[ 折射率 ]:
1.619

氟茚二酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK5700000

CHEMICAL NAME :: 1,3-Indandione, 2-(p-fluorophenyl)-

CAS REGISTRY NUMBER :: 957-56-2

BEILSTEIN REFERENCE NO. :: 2052411

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H9-F-O2

MOLECULAR WEIGHT :: 240.24

WISWESSER LINE NOTATION :: L56 BV DV CHJ CR DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

氟茚二酮安全信息

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2914700090

氟茚二酮合成路线

详细合成路线

氟茚二酮上下游产品

氟茚二酮上游产品

氟茚二酮下游产品

氟茚二酮海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%