苯酐

苯酐用途

【用途一】
用作分析试剂，也用于有机合成
【用途二】
是重要的有机化工原料之一，用于生产增塑剂、醇酸树脂、不饱和聚酯树脂、染料及颜料、医药及农药等
【用途三】
邻苯二甲酸酐简称苯酐，是杀菌剂灭菌丹、杀虫剂亚胺硫磷、除草剂灭草松的中间体。
【用途四】
苯酐是最重要的有机化工原料之一，其主要衍生物有邻苯二甲酸二丁酯、二辛酯和二异丁酯等，用作PVC等的增塑剂；还可用于生产不饱和聚酯树脂、醇酸树脂、染料及颜料、多种油漆、食品添加剂、医药中的缓泻剂酚酞、农药中的亚胺硫磷、灭草松以及糖精钠等。
【用途五】
标定碱的标准溶液，从仲醇、叔醇中分离伯醇。根据形成衍生物的溶点不同，检别伯胺和芳香族烃。除去苯中噻吩。

苯酐名称

[ CAS 号 ]:
85-44-9

[ 中文名 ]:
苯酐

[ 英文名 ]:
Phthalic anhydride

[中文别名 ]:

[英文别名 ]:

1,3-DIHYDRO-IMIDAZOL-2-ONE
4-imidazolin-2-one
MFCD00005918
1H-imidazol-2(3H)-one
phthallic anhydride
Phthalic anhydride
isobenzofuran-1,3-dione
1,3-dihydro-2H-imidazol-2-one
2-hydroxyimidazole
1,3-isobenzofurandione

苯酐物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
284 ºC

[ 熔点 ]:
129-132 ºC

[ 分子式 ]:
C₈H₄O₃

[ 分子量 ]:
148.116

[ 闪点 ]:
152 ºC

[ 精确质量 ]:
148.016037

[ PSA ]:
43.37000

[ LogP ]:
1.60

[ 外观性状 ]:
白色结晶固体带有令人窒息的气味

[ 蒸汽密度 ]:
5.1 (vs air)

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.613

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, moisture, strong acids. Dust may form an explosive mixture with air.

[ 水溶解性 ]:
6 g/L (20 ºC)

苯酐MSDS

详细MSDS(安全技术说明书)

苯酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3150000

CHEMICAL NAME :: Phthalic anhydride

CAS REGISTRY NUMBER :: 85-44-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 48

MOLECULAR FORMULA :: C8-H4-O3

MOLECULAR WEIGHT :: 148.12

WISWESSER LINE NOTATION :: T56 BVOVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >210 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/2H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 6 gm/kg/42D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - gastritis Gastrointestinal - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 mg/m3

SEX/DURATION :: male 45 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 203 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 6.1 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,3,1973 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,212,1971 OSHA PEL (Gen Indu):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (6.1 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FINLAND:TWA 2 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL-FRANCE:STEL 6 mg/m3 JAN 1993 OEL-GERMANY:TWA 5 mg/m3 JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 2 ppm (12 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.8 ppm (5 mg/m3);STEL 1.6 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3);STEL 4 ppm (24 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHTHALIC ANHYDRIDE-air:10H TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 59230 No. of Facilities: 10056 (estimated) No. of Industries: 128 No. of Occupations: 90 No. of Employees: 134716 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 59230 No. of Facilities: 5265 (estimated) No. of Industries: 72 No. of Occupations: 67 No. of Employees: 81312 (estimated) No. of Female Employees: 14675 (estimated)

苯酐安全信息

[ 符号 ]:

GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H317-H318-H334-H335

[ 警示性声明 ]:
P261-P280-P284-P304 + P340 + P312-P305 + P351 + P338 + P310-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R37/38;R41;R42/43

[ 安全声明 (欧洲) ]:
S23-S24/25-S26-S37/39-S46-S22

[ 危险品运输编码 ]:
2214

[ WGK德国 ]:
1

[ RTECS号 ]:
TI3150000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2917350000

苯酐合成路线

详细合成路线

苯酐上下游产品

苯酐上游产品

苯酐下游产品

苯酐制备

目前在工业生产中有两种苯酐原料路线，即邻二甲苯法(简称邻法)和萘法。生产工艺有三种：固定床氧化法；流化床气相氧化法和液相法。世界苯酐生产中以邻法固定床氧化技术为主，大约占苯酐生产总能力的90%以上。

1.邻二甲苯氧化法一般采用以五氧化二钒为主的钒系催化剂进行邻二甲苯的气相氧化，反应器多数为列管式固定床。将过滤后的无尘气经压缩；预热，与气化的邻二甲苯蒸气混合后进入反应器，在400-460℃进行氧化反应，进料空速2000-3000h-1，空气中邻二甲苯浓度40-60g、m2（标准），反应热由管外循环的熔盐带出。反应产物进入蒸气生器，被冷却的反应气经进一步冷却，回收粗苯酐。尾气经水洗回收顺丁烯二酸酐后放空。粗苯酐经减压粗馏，由塔丁分离出低沸点的顺丁烯二酸酐，甲基顺丁烯二酸酐及苯甲酸等；塔底物料经真空精馏，得到苯酐产品。原料消耗定额：邻二甲苯（98%）1138kg/t。

2.萘催化氧化法萘熔融气化后与空气在沸腾床或固定床反应器内，在催化剂五氧化二钒存在下，催化氧化生成苯酐气体，经冷凝热熔而得粗酐，通过热处理后再经减压蒸馏；冷凝；分离而得精苯酐。原料消耗定额：萘（95%以上）11250kg/t。

3.制法在微量磷酸存在下，用乙酸酐与邻苯二甲酸经加热回流制成：

苯酐海关

[ 海关编码 ]: 2917350000

[ 中文概述 ]:
HS:2917350000 邻苯二甲酸酐(苯酐) 增值税率:17.0% 退税率:9.0% 监管条件:AB 最低关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2917350000 isobenzofuran-1,3-dione VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:6.5% General tariff:30.0%

苯酐文献

Poly(butylene succinate-co-butylene adipate)/cellulose nanocrystal composites modified with phthalic anhydride.

Carbohydr. Polym. 134 , 52-9, (2015)

As a kind of biomass nanofiller for polymers, cellulose nanocrystal (CNC) has good mechanical properties and reinforcing capability. To improve the compatibility of poly(butylene succinate-co-butylene...

Encapsulation of fish oil with N-stearoyl O-butylglyceryl chitosan using membrane and ultrasonic emulsification processes.

Carbohydr. Polym. 123 , 432-42, (2015)

Fish oil-loaded microcapsules were prepared from oil-in-water emulsions using N-stearoyl O-butylglyceryl chitosan as shell material. The emulsions were prepared by both membrane and ultrasonic emulsif...

Microwave-assisted facile synthesis of a new tri-block chitosan conjugate with improved mucoadhesion.

Carbohydr. Polym. 130 , 213-21, (2015)

A new chitosan-based tri-block conjugate, O-PEG-chitosan-N-cysteine was synthesized using microwave irradiation. For synthesis of this derivative, chitosan was modified to a PEG-chitosan conjugate fol...

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苯酐