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呫吨酮

呫吨酮用途

Xanthone 是从山竹果中分离得到的,在癌变的不同阶段可控制细胞分裂和生长,凋亡,炎症和转移。Xanthone 具有抗氧化,抗肿瘤,抗过敏,抗炎,抗细菌,抗真菌和抗病毒活性。

呫吨酮名称

[ CAS 号 ]:
90-47-1

[ 中文名 ]:
占吨酮

[ 英文名 ]:
Xanthone

[中文别名 ]:

[英文别名 ]:

Xanthone
Dibenzo-g-pyrone
Benzophenone oxide
9-Xanthenone
MFCD00005060
9H-Xanthen-9-one
9-Oxoxanthene
Genicide
Diphenylene ketone oxide
Xanthenone

呫吨酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

研究领域 >> 炎症/免疫

[参考文献]

[1]. Shan T, et al.Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancerdrugs. Curr Mol Med. 2011 Nov;11(8):666-77.

呫吨酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
350.0±12.0 °C at 760 mmHg

[ 熔点 ]:
172-174 °C(lit.)

[ 分子式 ]:
C₁₃H₈O₂

[ 分子量 ]:
196.201

[ 闪点 ]:
169.8±13.1 °C

[ 精确质量 ]:
196.052429

[ PSA ]:
30.21000

[ LogP ]:
3.39

[ 外观性状 ]:
灰白色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.643

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

呫吨酮MSDS

呫吨酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZD5711000

CHEMICAL NAME :: Xanthen-9-one

CAS REGISTRY NUMBER :: 90-47-1

LAST UPDATED :: 199803

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H8-O2

MOLECULAR WEIGHT :: 196.21

WISWESSER LINE NOTATION :: T C666 BO IVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,25,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01611

呫吨酮安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
ZD5711000

[ 海关编码 ]:
2932999099

呫吨酮合成路线

呫吨酮上下游产品

呫吨酮上游产品

呫吨酮下游产品

呫吨酮制备

将水杨酸苯酯加热至275-285℃，开始反应并馏出生成的苯酚，继续升温达到350-355℃，所得产物经精制即为呫吨酮。

呫吨酮海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

呫吨酮文献

Synergistic Effects Between Thioxanthones and Oxacillin Against Methicillin-Resistant Staphylococcus aureus.

Microb. Drug Resist. 21 , 404-15, (2015)

The extensive use of antimicrobials is leaving medicine with few effective therapeutic options to treat many infections due to the fact that many organisms developed resistance to commonly used drugs....

Xanthones from roots, hairy roots and cell suspension cultures of selected Hypericum species and their antifungal activity against Candida albicans.

Plant Cell Rep. 34 , 1953-62, (2015)

Highest xanthone contents were found in Hypericum pulchrum and H. annulatum untransformed roots. The best anti- Candida activity was obtained for hairy roots extracts of H. tetrapterum clone 2 ATCC 15...

Identification and characterization of mefloquine efficacy against JC virus in vitro.

Antimicrob. Agents Chemother. 53 , 1840-9, (2009)

Progressive multifocal leukoencephalopathy (PML) is a rare but frequently fatal disease caused by the uncontrolled replication of JC virus (JCV), a polyomavirus, in the brains of some immunocompromise...

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呫吨酮