水杨酸苯酯

水杨酸苯酯用途

【用途一】
用作防腐剂，也用于制药、有机合成工业
【用途二】
用作塑料制品的紫外线吸收剂、增塑剂、防腐剂，用于药物合成、配制香精等
【用途三】
本品为一种紫外线吸收剂，用于塑料制品。但吸收波长范围较窄，光稳定性较差。也用作医药消毒防腐剂和用于有机合成。还用来制香料。
【用途四】
有机合成。比色法测定铁离子。塑料的光吸收剂，防止变色。乙烯基塑料的稳定剂。定香剂。

水杨酸苯酯名称

[ CAS 号 ]:
118-55-8

[ 中文名 ]:
水杨酸苯酯

[ 英文名 ]:
Phenyl salicylate

[中文别名 ]:

[英文别名 ]:

Phenyl-2-hydroxybenzoat
Salicylic acid phenyl ester
Seesorb 201
Benzoic acid, 2-hydroxy-, phenyl ester
Phenyl salicylate melting point
phenyl 2-hydroxybenzoate
Salicylic acid, phenyl ester
Seesorb K 201
salol
EINECS 204-259-2

水杨酸苯酯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
306.6±0.0 °C at 760 mmHg

[ 熔点 ]:
41-43 °C(lit.)

[ 分子式 ]:
C₁₃H₁₀O₃

[ 分子量 ]:
214.217

[ 闪点 ]:
137.3±13.2 °C

[ 精确质量 ]:
214.062988

[ PSA ]:
46.53000

[ LogP ]:
3.55

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
room temp

[ 稳定性 ]:
Light sensitive. Incompatible with strong oxidants. Flammable.

[ 水溶解性 ]:
dioxane: 0.1 g/mL, clear, colorless

水杨酸苯酯MSDS

水杨酸苯酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO6125000

CHEMICAL NAME :: Salicylic acid, phenyl ester

CAS REGISTRY NUMBER :: 118-55-8

BEILSTEIN REFERENCE NO. :: 0393969

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C13-H10-O3

MOLECULAR WEIGHT :: 214.23

WISWESSER LINE NOTATION :: QR BVOR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,837,1976

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,149,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 15,561,1895 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 mg/kg

SEX/DURATION :: female 7-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 7-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80479 No. of Facilities: 241 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 2943 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80479 No. of Facilities: 471 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5712 (estimated) No. of Female Employees: 2297 (estimated)

水杨酸苯酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
VO6125000

[ 海关编码 ]:
2918230000

水杨酸苯酯合成路线

水杨酸苯酯上下游产品

水杨酸苯酯上游产品

水杨酸苯酯下游产品

水杨酸苯酯制备

1.将28kg工业苯酚、40kg工业水杨酸投入干燥的反应釜内，加热熔融，严格控制温度(130±2)℃。搅拌下缓缓滴入三氯化磷16kg进行反应，加毕，仍保持(130±2)℃，搅拌4h。排尽反应生成的氯化氢后，趁热用两倍的65℃热水洗涤，静置40min，分去水层后，再洗涤1次。用5%的碳酸氢钠溶液中和至pH为8，再用65℃的热水洗至pH值为7。静置，分去水层，在油层中加入约1倍的蒸馏水搅拌均匀、冷却、结晶、活性炭脱色，即得成品。

水杨酸苯酯海关

[ 海关编码 ]: 2918230000

[ 中文概述 ]:
2918230000 水杨酸其他酯. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

水杨酸苯酯文献

Leaching of additives and degradation products from cold-cured orthodontic resins.

Acta Odontol. Scand. 52(3) , 150-6, (1994)

Unstimulated saliva was collected from orthodontic patients and subjected to combined gas-chromatography and gas-chromatography/mass-spectrometry analyses. Saliva was collected before insertion of rem...

In vitro transformation of hamster embryo cells by 3-(N-salicyloyl)amino-1,2,4-triazole.

Toxicol. Lett. 7(3) , 211-5, (1981)

The in vitro carcinogenic activities of 3-(N-salicyloyl)amino-1,2,4-triazole (SAT) and its two components, 3-amino-1,2,4-triazole and phenyl salicylate were examined in a transformation assay with cry...

Fragrance material review on phenyl salicylate.

Food Chem. Toxicol. 45 Suppl 1 , S472-6, (2007)

A toxicologic and dermatologic review of phenyl salicylate when used as a fragrance ingredient is presented.

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