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(D-PRO4,D-TRP7·9,NLE11)-SUBSTANCE P (4-11)

用途

[D-Pro4,D-Trp7,9,Nle11]P物质(4-11)是一种有效的神经激肽NK1拮抗剂。[D-Pro4,D-Trp7,9,Nle11]物质P(4-11)抑制金蛋白物质P(GPSP)和物质P(SP)的作用[1]。

名称

[ CAS 号 ]:
89430-34-2

[ 中文名 ]:
(D-PRO4,D-TRP7·9,NLE11)-SUBSTANCE P (4-11)

[ 英文名 ]:
[D-Pro4,D-Trp7,9,Nle11]-Substance P (4-11)

[英文别名 ]:

4-Pro-7,9-Trp-11-nle-substance p (4-11)
substance P (4-11),Pro(4)-Trp(7,9)-Nle(11)
Substance P,fragment 4-11,[D-Pro4,D-Trp7,9,Nle11]
(D-pro4,D-trp7,9,nle11)-substance P*fragment 4-11
Pttnl-sp(4-11)
H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2
SUBSTANCE P [D-PRO4,D-TRP7,9,NLE11]-FRAGMENT 4-11
(D-PRO4,D-TRP7,9,NLE11)-SUBSTANCE P (4-11)
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2

生物活性

[ 描述 ]:

[D-Pro4,D-Trp7,9,Nle11]P物质(4-11)是一种有效的神经激肽NK1拮抗剂。[D-Pro4,D-Trp7,9,Nle11]物质P(4-11)抑制金蛋白物质P(GPSP)和物质P(SP)的作用[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

[体外研究]

[D-Pro4,D-Trp7,9,Nle11]P物质(4-11)(100nM)剂量不会产生直接的舒张或收缩作用,但会显著降低SP和GPSP引起的血管舒张[1]。

[参考文献]

[1]. Cathieni M M, et al. Pharmacological Evidence that Gold-Protein-Substance P Complex Activates Neurokinin NK1 Receptors[J]. Cellular Physiology & Biochemistry, 1995, 5(2):85-95.

物理化学性质

[ 分子式 ]:
C₅₈H₇₇N₁₃O₁₀

[ 分子量 ]:
1116.31000

[ 精确质量 ]:
1115.59000

[ PSA ]:
376.58000

[ LogP ]:
6.24130

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

A new analogue of substance P with antagonistic properties in renal and pulmonary arteries.

Acta Physiol. 15 , 10, (1989)

The effects of a new analogue of substance P (SP-A) and its interaction with substance P (SP) were studied in vitro isolated preparations from rabbit renal arteries and rat renal and pulmonary arterie...

Synthesis of substance P antagonists: [D-Pro4, D-Trp7,9,Nle11]-substance P(4-11).

Pharmazie 39(1) , 65-7, (1984)

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