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(R)-(+)-SKF-38393 盐酸盐

(R)-(+)-SKF-38393 盐酸盐用途

(R) -SKF38393((±)-SKF-38393)盐酸盐是一种强效、选择性的D1多巴胺受体拮抗剂。(R) -SKF 38393盐酸盐抑制G蛋白偶联的内向整流钾(GIRK)通道[1]。

(R)-(+)-SKF-38393 盐酸盐名称

[ CAS 号 ]:
81702-42-3

[ 中文名 ]:
(R)-(+)-SKF38393盐酸盐

[ 英文名 ]:
R(+)-SKF-38393A

[英文别名 ]:

MFCD00055189

(R)-(+)-SKF-38393 盐酸盐生物活性

[ 描述 ]:

(R) -SKF38393((±)-SKF-38393)盐酸盐是一种强效、选择性的D1多巴胺受体拮抗剂。(R) -SKF 38393盐酸盐抑制G蛋白偶联的内向整流钾(GIRK)通道[1]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

[体外研究]

(R) -SKF 38393盐酸氢内酯((±)-SKF38393；0-100µM)阻断 AtT-20细胞中由生长抑素或 D3多巴胺受体诱导的内源围梁电流,IC50值为 268 nM[1]

[参考文献]

[1]. Kuzhikandathil EV, et, al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26.

(R)-(+)-SKF-38393 盐酸盐物理化学性质

[ 分子式 ]:
C₁₆H₁₈ClNO₂

[ 分子量 ]:
291.77

[ 精确质量 ]:
291.10300

[ PSA ]:
52.49000

[ LogP ]:
3.50620

[ 储存条件 ]:
室温，干燥，密封

(R)-(+)-SKF-38393 盐酸盐MSDS

详细MSDS(安全技术说明书)

(R)-(+)-SKF-38393 盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36-22

[ 危险品运输编码 ]:
NONH for all modes of transport

(R)-(+)-SKF-38393 盐酸盐文献

Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.

J. Neurosci. 31 , 5512-25, (2011)

An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors,...

Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.

Bioorg. Med. Chem. 19 , 5420-31, (2011)

To assess the effect of conformational mobility on receptor activity, the β-phenyl substituent of dopamine D(1) agonist ligands of the phenylbenzazepine class, (±)-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]...

Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine.

Psychopharmacology 107 , 217, (1992)

The present study was designed to assess the behavioral similarity of the effects of prototype dopamine receptor-subtype selective agonists and cocaine. Squirrel monkeys (N = 4) were trained with food...

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