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吖啶黄素

吖啶黄素用途

【用途一】
添加于李氏菌增菌肉汤基础中。

吖啶黄素名称

[ CAS 号 ]:
8048-52-0

[ 中文名 ]:
吖啶黄

[ 英文名 ]:
ACRIFLAVINE

[中文别名 ]:

[英文别名 ]:

ACRIFLAVINE
EUFLAVINE
diacrid
flavipin
Trypaflavine
gonacin
flavine
Neutroflavine
EUFLAVIN
angiflan

吖啶黄素生物活性

[ 描述 ]:

Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

研究领域 >> 癌症

染料试剂

研究领域 >> 感染

[体外研究]

Acriflavine被确定为MCT4的有效抑制剂,可抑制Basigin和MCT4之间的结合。 Acriflavine显着抑制几种胶质母细胞瘤神经球系的生长和自我更新潜能[1]。 HIF-1抑制剂acriflavine降低CML细胞的存活和生长。它针对CML细胞的干细胞潜力[2]。

[体内研究]

Acriflavine治疗抑制肿瘤内VEGF的表达和肿瘤血管形成[1]。在小鼠CML模型中,acriflavine可以减少白血病的发展并减少LSC的维持[2]。 Acriflavine在小鼠乳腺癌模型中阻止肿瘤生长。舒尼替尼与acriflavine联合应用可显着降低血管内皮生长因子和TGF-β的表达,减少肿瘤血管,随后增加肿瘤内坏死和凋亡[3]。

[动物实验]

小鼠：从骨髓移植后第7天开始，每天用acriflavine（8 mg / kg）或PBS通过腹腔注射治疗CML小鼠10天[2]。

[参考文献]

[1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.

[2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.

[3]. Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45.

[相关活性小分子]

吖啶黄素物理化学性质

[ 熔点 ]:
179-181 °C

[ 分子式 ]:
C₁₄H₁₄ClN₃

[ 分子量 ]:
259.73

[ PSA ]:
120.85000

[ LogP ]:
3.86310

[ 外观性状 ]:
深橙色至褐色-红色粉末

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶；可溶于：乙醇；不溶：氯仿,乙醚

吖啶黄素MSDS

详细MSDS(安全技术说明书)

吖啶黄素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR9660000

CHEMICAL NAME :: Acridinium, 3,6-diamino-10-methyl-, chloride mixed with 3,6-acridinediamine

CAS REGISTRY NUMBER :: 8048-52-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C14-H14-N3.Cl.C13-H11-N3

MOLECULAR WEIGHT :: 469.03

WISWESSER LINE NOTATION :: T C666 BKJ B1 EZ MZ &G &T C666 BNJ EZ MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/60W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 25 mg/L

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 19,55,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,31,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,31,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1531 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 40 (estimated) No. of Female Employees: 10 (estimated)

吖啶黄素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R37/38;R41;R50/53

[ 安全声明 (欧洲) ]:
S26-S39-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AR9660000

[ 海关编码 ]:
38249064

吖啶黄素海关

[ 海关编码 ]: 38249064

吖啶黄素文献

Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.

Free Radic. Res. 48(10) , 1206-17, (2014)

Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance...

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.

Proc. Natl. Acad. Sci. U. S. A. 112 , 9112-7, (2015)

Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug tar...

The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015)

Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th...

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