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阿坎酸钙

阿坎酸钙用途

Acamprosate calcium(Campral EC)是GABA受体激动剂和谷氨酸能系统调节剂。

阿坎酸钙名称

[ CAS 号 ]:
77337-73-6

[ 中文名 ]:
阿坎酸钙

[ 英文名 ]:
Acamprosate calcium

[中文别名 ]:

[英文别名 ]:

Campral
Acamprosate calcium
MFCD00886588
calcium acetylhomotaurinate
Calciumbis[3-(acetylamino)propan-1-sulfonat]
CA-Aota
Alcomed
Sobriol
Calcium bis(3-acetamido-1-propanesulfonate)
Calcium Bisacetyl Homotaurine

阿坎酸钙生物活性

[ 描述 ]:

Acamprosate calcium(Campral EC)是GABA受体激动剂和谷氨酸能系统调节剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

[参考文献]

[1]. Preuss UW. Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.).Alcohol Clin Exp Res. 2012 Jun;36(6):967-9. doi: 10.1111/j.1530-0277.2012.01827.x.

[2]. Witkiewitz K, Saville K, Hamreus K.Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.Ther Clin Risk Manag. 2012;8:45-53.

[3]. Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15.

[4]. Palucha-Poniewiera A, Pilc A.Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6.

[5]. Hinton DJ, et al. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.Neuropharmacology. 2012 Jun;62(8):2480-8.

[相关活性小分子]

阿坎酸钙物理化学性质

[ 熔点 ]:
>300ºC

[ 分子式 ]:
C₅H₁₀NO₄S_.1/₂Ca

[ 分子量 ]:
200.24

[ PSA ]:
189.36000

[ LogP ]:
1.05900

[ 外观性状 ]:
白色,无气味的或几乎无气味的粉末

[ 储存条件 ]:
Room temp

[ 水溶解性 ]:
水溶性：完全溶解

阿坎酸钙MSDS

详细MSDS(安全技术说明书)

阿坎酸钙安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924199090

阿坎酸钙海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

阿坎酸钙文献

Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy.

Sci. Rep. 5 , 7608, (2015)

Alzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational th...

Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat.

Neuropsychopharmacology 39(11) , 2601-10, (2014)

Since its discovery, the nociceptin/orphanin FQ (N/OFQ)-NOP receptor system has been extensively investigated as a promising target to treat alcoholism. Encouraging results obtained with the endogenou...

Acamprosate calcium as augmentation therapy for anxiety disorders.

Ann. Pharmacother. 44 , 1930-2, (2010)

Glutamate is a major excitatory neurotransmitter, while γ-aminobutyric acid (GABA) is a predominant inhibitory neurotransmitter in the central nervous system. This GABA-glutamate imbalance is thought ...

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