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BAM-12P

BAM-12P用途

BAM-12P是一种内源性阿片肽,是一种新型的促Met脑啡肽。BAM-12P可以激活人κ-阿片受体(hKOR),EC50为101nM,pEC50为6.99。BAM-12P是CXCR7的配体,EC50为175nM[1][2][3]。

BAM-12P名称

[ CAS 号 ]:
75513-71-2

[ 中文名 ]:
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU

[ 英文名 ]:
Bovine adrenal medulla dodecapeptide

[英文别名 ]:

BOVINE ADRENAL MEDULLA-12P
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU
Peptide E(1-12)
BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
BOVINE ANDRENAL MEDULLA DODECAPEPTIDE
YGGFMRRVGRPE
BOVINE ADRENAL MEDULLA DODECAPEPTIDE

BAM-12P生物活性

[ 描述 ]:

BAM-12P是一种内源性阿片肽,是一种新型的促Met脑啡肽。BAM-12P可以激活人κ-阿片受体(hKOR),EC50为101nM,pEC50为6.99。BAM-12P是CXCR7的配体,EC50为175nM[1][2][3]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CXCR

信号通路 >> 神经信号通路 >> 阿片受体

信号通路 >> 免疫及炎症 >> CXCR

研究领域 >> 神经疾病

[ 靶点 ]

human κ-opioid receptor (hKOR):101 nM (EC50)

human κ-opioid receptor (hKOR):6.99 (pEC50)

CXCR7:175 nM (EC50)

[体外研究]

班-12P在豚鼠回肠试验中显示出有效的阿片活性,国际50为 15.5 nM[2]

[参考文献]

[1]. K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun. 1980 Aug 29;95(4):1482-8.

[2]. Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155(6):1323-36.

[3]. Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.

BAM-12P物理化学性质

[ 分子式 ]:
C₆₂H₉₇N₂₁O₁₆S

[ 分子量 ]:
1424.63000

[ 精确质量 ]:
1423.71000

[ PSA ]:
643.16000

[ LogP ]:
2.50620

[ 储存条件 ]:
-20°C

BAM-12PMSDS

详细MSDS(安全技术说明书)

BAM-12P安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

BAM-12P文献

Substrate specificity of a novel serine protease from soybean [Glycine max (L.) Merrill].

J. Biochem. 119(6) , 1094-9, (1996)

The substrate specificity of a novel serine protease isolated from soybean seeds, cultivar Keburi, was investigated using various peptide-MCAs and several neuropeptides involving single and paired bas...

Opioid activity of pro-enkephalin-derived peptides in mouse vas deferens and guinea pig ileum.

Neurosci. Lett. 61(3) , 267-71, (1985)

The inhibitory activity of several pro-enkephalin A-derived opioid peptides, containing the sequence of Met-enkephalin, was evaluated in two isolated organ preparations sensitive to opioids, the guine...

A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.

Biochem. Biophys. Res. Commun. 97 , 1283, (1980)

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