5'-三磷酸腺苷,高碘酸盐氧化钠盐

5'-三磷酸腺苷,高碘酸盐氧化钠盐用途

Oxidized ATP (oATP) trisodium salt 是一种广谱 P2 受体抑制剂。Oxidized ATP trisodium salt 不可逆地拮抗 P2X7R 激活。Oxidized ATP trisodium salt 抑制 C 反应蛋白 (CRP) 诱导的 NLRP3 炎性体激活。Oxidized ATP (oATP) trisodium salt 可用于动脉粥样硬化研究。

5'-三磷酸腺苷,高碘酸盐氧化钠盐名称

[ CAS 号 ]:
71997-40-5

[ 中文名 ]:
腺苷-5`-三磷酸钠盐,高碘酸氧化过的

[ 英文名 ]:
ADENOSINE 5'-TRIPHOSPHATE,PERIODATE OXIDIZED SODIUM SALT

[英文别名 ]:

MFCD00056956

5'-三磷酸腺苷,高碘酸盐氧化钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> NOD样受体(NLR)

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> P2X受体

[ 靶点 ]

NLRP3 inflammasome

P2X7 Receptor

[体内研究]

氧化ATP(300μg/只小鼠,腹腔注射,每周两次)三钠盐可改善B6小鼠诱导的小鼠实验性自身免疫性葡萄膜炎(EAU)[2]。动物模型：诱导小鼠实验性自身免疫性葡萄膜炎(EAU)[2]剂量：300μg/小鼠给药：腹腔注射。结果：如眼底镜和病理检查所示,显示几乎未被发现的EAU。血清IL-17水平下降。缓解了自身反应性T细胞反应。

[参考文献]

[1]. Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40.

[2]. Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953.

5'-三磷酸腺苷,高碘酸盐氧化钠盐物理化学性质

[ 分子式 ]:
C₁₀H₁₁N₅Na₃O₁₃P₃

[ 分子量 ]:
571.11

[ 储存条件 ]:
−20°C

5'-三磷酸腺苷,高碘酸盐氧化钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

5'-三磷酸腺苷,高碘酸盐氧化钠盐文献

Involvement of a P2X7 Receptor in the Acrosome Reaction Induced by ATP in Rat Spermatozoa.

J. Cell Physiol. 230 , 3068-75, (2015)

The acrosome reaction (AR) is the exocytosis of the acrosomal vesicle in response to different physiological and non-physiological stimuli. Particularly in mammals, the AR is needed for sperm to fuse ...

P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions.

J. Virol. 89 , 9368-82, (2015)

HIV-1 Env glycoprotein-mediated fusion is initiated upon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5. Whereas these interactions are thought to be necessary and sufficient to pro...

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance.

Proc. Natl. Acad. Sci. U. S. A. 112(9) , 2835-40, (2015)

Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated period...

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