<生产厂家价格>

2-羟基-1-萘甲醛

2-羟基-1-萘甲醛用途

CFL-137是一种强效的KRasG12C抑制剂。CFL-137显示出抗增殖作用。CFL-137显示出抗癌活性。CFL-137具有研究癌症的潜力[1]。

2-羟基-1-萘甲醛名称

[ CAS 号 ]:
708-06-5

[ 中文名 ]:
2-羟基-1-萘甲醛

[ 英文名 ]:
2-Hydroxy-naphthaldehyde

[中文别名 ]:

[英文别名 ]:

2-Hydroxy-1-naphthaldehyde
2-hydroxynaphthalene-1-carboxaldehyde
1-naphthalenecarboxaldehyde, 2-hydroxy
1-Naphthalenecarboxaldehyde, 2-hydroxy-
EINECS 211-902-0
2-Hydroxy-naphthaldehyde
MFCD00004005
.β.-Hydroxy-.α.-naphthaldehyde

2-羟基-1-萘甲醛生物活性

[ 描述 ]:

CFL-137是一种强效的KRasG12C抑制剂。CFL-137显示出抗增殖作用。CFL-137显示出抗癌活性。CFL-137具有研究癌症的潜力[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯

[ 靶点 ]

KRAS(G12C)

[体外研究]

CFL-137(72小时)显示出抗增殖作用,对 H1792、SW1573、MiaPaca2、H358、A549、SW480、PANC-1、LCLC-103H、BxPC3、HCA-7、MRC-5、HUVEC-RT、CCD-986Sk细胞的 IC50值分别为 11.4、24.2、24.5、12.3、43.3、44.5、27.63、32.4、46.9、26.2、25.0、10.8、66.2µM[1]

[体内研究]

CFL-137(5 mg/kg,5次治疗；15毫克/千克,5次治疗；30毫克/千克,3次治疗；腹腔注射)减少皮下人肺癌 H1792(KRasG12C突变体) 和 LCLC-103H(KRasWT)小鼠肿瘤模型的生长[1] 动物模型：NOD/SCID雌性小鼠(KRasWT(LCLC-103H)或KRasG12C(H1792)肿瘤)[1]剂量：5 mg/kg,5次治疗；15 mg/kg,5个处理；30 mg/kg,3次治疗给药：I.p.结果：在KRasG12C突变模型中,与对照组相比,肿瘤生长减少了32.5%。

[参考文献]

[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.

2-羟基-1-萘甲醛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
305.8±0.0 °C at 760 mmHg

[ 熔点 ]:
82-85ºC

[ 分子式 ]:
C₁₁H₈O₂

[ 分子量 ]:
172.18

[ 闪点 ]:
134.3±13.0 °C

[ 精确质量 ]:
172.052429

[ PSA ]:
37.30000

[ LogP ]:
2.84

[ 外观性状 ]:
黄色-米色-棕色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.719

[ 储存条件 ]:
室温

2-羟基-1-萘甲醛MSDS

详细MSDS(安全技术说明书)

2-羟基-1-萘甲醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ0300000

CHEMICAL NAME :: 1-Naphthaldehyde, 2-hydroxy-

CAS REGISTRY NUMBER :: 708-06-5

BEILSTEIN REFERENCE NO. :: 0742777

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H8-O2

MOLECULAR WEIGHT :: 172.19

WISWESSER LINE NOTATION :: T66J BVH CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1170 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),85,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7250 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume decreased Blood - change in clotting factors Blood - changes in leukocyte (WBC) count

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),86,1986

2-羟基-1-萘甲醛安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H400

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3077 9

[ WGK德国 ]:
2

[ RTECS号 ]:
QJ0300000

[ 海关编码 ]:
2912499000

2-羟基-1-萘甲醛合成路线

详细合成路线

2-羟基-1-萘甲醛上下游产品

2-羟基-1-萘甲醛上游产品

2-羟基-1-萘甲醛下游产品

2-羟基-1-萘甲醛制备

由2-萘酚与氯仿反应而得。在反应锅内加入乙醇、2-萘酚，加热至40℃，搅拌0.5h。再加入30%氢氧化钠溶液，升温至75℃，滴加氯仿，控制反应温度为78℃。加完后，在78℃保温2h。然后升至90℃，蒸出乙醇和过量氯仿，蒸完后，冷却至30℃以下，静置分层6h。过滤，滤液加水搅拌，加热至60℃，用盐酸中和至pH为2-3。冷却，过滤，滤饼在60℃以下干燥，得成品。

2-羟基-1-萘甲醛海关

[ 海关编码 ]: 2912499000

[ 中文概述 ]:
2912499000. 其他醛醚、醛酚及含其他含氧基的醛. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

2-羟基-1-萘甲醛文献

Synthesis, spectroscopic, coordination and biological activities of some transition metal complexes containing ONO tridentate Schiff base ligand.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 149 , 771-87, (2015)

The main target of this paper is to get an interesting data for the preparation and characterizations of metal oxide (MO) nanoparticles using H2L Schiff base complexes as precursors through the therma...

Schiff bases attached L-glutamine and L-asparagine: first investigation on antimutagenic and antimicrobial analyses.

Artif. Cells. Nanomed. Biotechnol. 42(3) , 199-204, (2014)

This study was conducted to evaluate the antimutagenic and antimicrobial activities of Schiff bases attached L-glutamine and L-asparagine. Antibacterial activities of the compounds against S. aureus, ...

Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.

J. Clin. Invest. 124(6) , 2585-98, (2014)

Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER stress-associated transcri...

更多文献