咪鲜安

咪鲜安用途

咪鲜胺是一种咪唑类抗真菌药物,通过抑制细胞色素P450依赖的羊角甾醇14α-去甲基化而抑制麦角甾醇的生物合成,导致真菌细胞膜破裂和细胞死亡。咪鲜胺体外抑制人胎盘微粒体芳香化酶(IC50=40nm)。咪鲜胺还可作为雌激素受体(ER)和雄激素受体(AR)的拮抗剂(IC50s分别为25μM和4μM),并激活芳香烃受体(AhR；EC50=1μM)。

咪鲜安名称

[ CAS 号 ]:
67747-09-5

[ 中文名 ]:
咪鲜胺

[ 英文名 ]:
prochloraz

[中文别名 ]:

[英文别名 ]:

Prochloraz
Abarit
MASTER
EINECS 266-994-5
octave
FORTAK
sprint
T5N CNJ AVN3&2OR BG DG FG
EYETAK
MFCD00078735

咪鲜安生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

信号通路 >> 抗感染 >> 真菌

信号通路 >> 免疫及炎症 >> 芳基烃受体

信号通路 >> 其他 >> 雄激素受体

咪鲜安物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
499.8±55.0 °C at 760 mmHg

[ 熔点 ]:
46-49°C

[ 分子式 ]:
C₁₅H₁₆Cl₃N₃O₂

[ 分子量 ]:
376.665

[ 闪点 ]:
256.1±31.5 °C

[ 精确质量 ]:
375.030823

[ PSA ]:
47.36000

[ LogP ]:
3.98

[ 外观性状 ]:
无色固体

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.597

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

咪鲜安MSDS

详细MSDS(安全技术说明书)

咪鲜安毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4000400

CHEMICAL NAME :: 1H-Imidazole-1-carboxamide, N-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)-

CAS REGISTRY NUMBER :: 67747-09-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C15-H16-Cl3-N3-O2

MOLECULAR WEIGHT :: 376.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C249,1991

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 37,121,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 37,121,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1231,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C249,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A475,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 3132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,701,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 37,121,1983

咪鲜安安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R50/53

[ 安全声明 (欧洲) ]:
S60-S61-S36/37-S26

[ 危险品运输编码 ]:
UN 3077

[ RTECS号 ]:
NI4000400

[ 包装等级 ]:
III

[ 海关编码 ]:
2933290012

咪鲜安上下游产品

咪鲜安上游产品

咪鲜安下游产品

咪鲜安制备

1.以2,4,6-三氯酚为原料，依次与1,2-二溴乙烷、丙胺、光气、咪唑反应制得咪鲜胺

2.咪唑与光气作用后生成的中间产物和2,4,6-三氯酚依次与12-二氯乙烷、丙胺作用的中间产物作用制得。

咪鲜安海关

[ 海关编码 ]: 2933290012

[ 中文概述 ]:
2933290012 抑霉唑,咪菌腈,咪菌酮,咪鲜胺等〔包括克霉唑,咪鲜胺锰盐〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933290012 1-((2-chlorophenyl)diphenylmethyl)-1h-imidazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

咪鲜安文献

LC-MS analysis of the plasma metabolome--a novel sample preparation strategy.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 83-8, (2015)

Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metab...

Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola.

PLoS ONE 6(6) , e20973, (2011)

A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella graminicola is presented, attained by homo...

Human poisoning with prochloraz imidazole fungicide.

Clin. Toxicol. (Phila.) 51(10) , 1237-8, (2013)

更多文献

咪鲜安