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丙胺

丙胺用途

正丙胺为有机合成原料，用于药物、涂料、农药、橡胶、纤维、纺织品及树脂的整理剂、石油添加剂和防腐剂，还用作试剂等。在农药方面，可生产除草剂氯乙氟灵和环丙氟灵。一正丙胺的用途不如二正丙胺重要。
主要用于制造纤维和工程塑料。
用于生产杀菌剂。

丙胺名称

[ CAS 号 ]:
107-10-8

[ 中文名 ]:
正丙胺

[ 英文名 ]:
Propylamine

[中文别名 ]:

[英文别名 ]:

Propylamin
PROPANEAMINE
EINECS 203-462-3
Propan-1-amine
n-C3H7NH2
1-Propanamine
mono-n-propyl amine
MFCD00008205
Propanamine
1-Propylamine

丙胺物理化学性质

[ 密度 ]:
0.719 g/mL at 25 °C(lit.)

[ 沸点 ]:
48 °C(lit.)

[ 熔点 ]:
-83 °C

[ 分子式 ]:
C₃H₉N

[ 分子量 ]:
59.11030

[ 闪点 ]:
−35 °F

[ 精确质量 ]:
59.07350

[ PSA ]:
26.02000

[ LogP ]:
1.05540

[ 外观性状 ]:
吸湿的无色液体,带有氨气味

[ 蒸汽密度 ]:
2 (vs air)

[ 蒸汽压 ]:
329mmHg at 25°C

[ 折射率 ]:
n20/D 1.388(lit.)

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Highly flammable. Note low flash point. Readily forms explosive mixtures with air. Incompatible with oxidising agents, strong acids. Store cool.

[ 水溶解性 ]:
soluble

丙胺MSDS

丙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UH9100000

CHEMICAL NAME :: Propylamine

CAS REGISTRY NUMBER :: 107-10-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C3-H9-N

MOLECULAR WEIGHT :: 59.13

WISWESSER LINE NOTATION :: Z3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/12/1968 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 8/12/1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2310 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Liver - hepatitis (hepatocellular necrosis), diffuse

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,343,1960

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,238,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,102,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 560 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2500 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 ppm/7H/50D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 1,343,1960 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND:STEL 5 ppm (12 mg/m3);Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83632 No. of Facilities: 339 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 1723 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83632 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

丙胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H311 + H331-H314-H412

[ 警示性声明 ]:
P210-P261-P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/21/22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S16-S7/9-S36

[ 危险品运输编码 ]:
UN 1277 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
UH9100000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

丙胺合成路线

丙胺上下游产品

丙胺上游产品

丙胺下游产品

丙胺制备

1.正丙醇与氨反应，丙腈或丙烯腈加氢，或者由丙醛还原氨化都可以制备丙胺。反应得到一正丙胺、二正丙胺、三正丙胺的混合物。经分馏而得各纯组分。正丙醇与氨反应的方法是工业上采用的方法。1.正丙醇法以正丙醇为原料，在催化剂镍-铜-氧化铝（Ni-Cu-Al2O3）作用下，在190±10℃温度下进行反应，脱氢生成丙醛，与氨加成脱水得亚胺，通过丙醇和氨的比例控制，再加氢可得产品正丙胺，但同时还有二丙胺、三丙胺生成（参见“三丙胺”）。

2.硝基丙烷法硝基正丙烷低压催化加氢得正丙胺。

丙胺文献

Discovery of optimal zeolites for challenging separations and chemical transformations using predictive materials modeling.

Nat. Commun. 6 , 5912, (2015)

Zeolites play numerous important roles in modern petroleum refineries and have the potential to advance the production of fuels and chemical feedstocks from renewable resources. The performance of a z...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development.

Phytochemistry 110 , 58-71, (2015)

Alkamides and N-acylethanolamines (NAEs) are bioactive, amide-linked lipids that influence plant development. Alkamides are restricted to several families of higher plants and some fungi, whereas NAEs...

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丙胺