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地索奈德

地索奈德用途

Desonide是非氟化皮质类固醇抗炎剂,能作用于糖皮质激素受体。

地索奈德名称

[ CAS 号 ]:
638-94-8

[ 中文名 ]:
地索奈德

[ 英文名 ]:
Desonide

[英文别名 ]:

Prednacinolone
16a,17a-Isopropylidenedioxyprednisolone
Desowen
Locapred
Desonide
Sterax
16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide
16a-Hydroxyprednisolone-16a,17-acetonide
Steroderm
16a-Hydroxyprednisolone Acetonide

地索奈德生物活性

[ 描述 ]:

Desonide是非氟化皮质类固醇抗炎剂,能作用于糖皮质激素受体。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.

[2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.

[3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.

[相关活性小分子]

地索奈德物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
580.1±50.0 °C at 760 mmHg

[ 熔点 ]:
274 - 275ºC

[ 分子式 ]:
C₂₄H₃₂O₆

[ 分子量 ]:
416.507

[ 闪点 ]:
196.9±23.6 °C

[ 精确质量 ]:
416.219879

[ PSA ]:
93.06000

[ LogP ]:
2.62

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
Refrigerator

地索奈德毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU2800000

CHEMICAL NAME :: Prednisolone-16,17-acetonide, 16-alpha-hydroxy-

CAS REGISTRY NUMBER :: 638-94-8

LAST UPDATED :: 199203

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H32-O6

MOLECULAR WEIGHT :: 416.56

WISWESSER LINE NOTATION :: T F5 E5 B666 GO IO RV AHTTTT&J A1 CQ E1 FV1Q H1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 20,522,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,111,1970

地索奈德安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2937210000

地索奈德合成路线

详细合成路线

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地索奈德海关

[ 海关编码 ]: 2937210000