西伐丁

西伐丁用途

Cevadine 是一种电压敏感钠通道 (sodium channel) 激动剂。Cevadine 具杀虫 (insecticidal) 活性。

西伐丁名称

[ CAS 号 ]:
62-59-9

[ 中文名 ]:
西伐丁

[ 英文名 ]:
VERATRINE

[中文别名 ]:

[英文别名 ]:

西伐丁生物活性

[ 描述 ]:

Cevadine 是一种电压敏感钠通道 (sodium channel) 激动剂。Cevadine 具杀虫 (insecticidal) 活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道
研究领域 >> 感染

[参考文献]

[1]. Bloomquist JR. Ion channels as targets for insecticides. Annu Rev Entomol. 1996;41:163-90.  

西伐丁物理化学性质

[ 密度 ]:
1.41g/cm3

[ 沸点 ]:
733.3ºC at 760 mmHg

[ 熔点 ]:
213.5ºC (with decomposition)

[ 分子式 ]:
C32H49NO9

[ 分子量 ]:
591.73

[ 闪点 ]:
397.3ºC

[ 精确质量 ]:
591.34100

[ PSA ]:
160.15000

[ LogP ]:
0.92910

[ 折射率 ]:
1.647

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

西伐丁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FL5600000
CHEMICAL NAME :
Cevane-3-beta,4-beta,12,14,16-beta,17,20-heptol, 4,9-epoxy-, 3-(2-methylcrotonate), (Z)-
CAS REGISTRY NUMBER :
62-59-9
BEILSTEIN REFERENCE NO. :
0072445
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C32-H49-N-O9
MOLECULAR WEIGHT :
591.82
WISWESSER LINE NOTATION :
T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ EQ GQ IQ I1 M1 RQ U1 A&OV1UY1&1 B&Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 76,847,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4900 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 26,383,1946
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
116 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,412,1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 26,383,1946

西伐丁安全信息

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

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