62-59-9

• 常用中文名：西伐丁
• 常用英文名：VERATRINE
• CAS号：62-59-9
• 分子式：C₃₂H₄₉NO₉
• 分子量：591.73
• 相关类别： 信号通路 跨膜转运 钠通道
• 发布时间：2018-04-04 08:00:00
• 更新时间：2026-07-01 21:43:58
• Cevadine 是一种电压敏感钠通道 (sodium channel) 激动剂。Cevadine 具杀虫 (insecticidal) 活性。

名称

• 中文名: 西伐丁
• 英文名: veratrine
• 中文别名: 塞凡定/HPLC; 瑟瓦定; 塞凡定; 藜蘆鹼
• 英文别名: Cevadene; 4α,9-oxycevane-3β,4,12,14,16β,17,20-htol 3-[(Z)-2-methyl-2-butenoate]; alpha.-Veratrine; (z)-4-alpha,9-oxycevane-3-beta,4,12,14,16-beta,17,20-htol3-(2-methyl-2-b; (z)-te; Cevane-3,4,12,14,16,17,20-htol, 4,9-oxy-, 3-[(2Z)-2-methyl-2-butenoate], (3β,4α,16β); Cevane-3,4,12,14,16,17,20-htol, 4,9-oxy-, 3-(2-methyl-2-butenoate), [3.beta.(Z),4.alpha.,16.beta.]; 4-beta,12,14,16-beta,17,20-htol,4,9-oxy-cevane-3-bet3-(2-methylcrotona; cevadin; VERATRINE(RG); Cevane-3.beta.,4.beta.,12,14,16.beta.,17,20-htol, 4,9-oxy-, 3-((Z)-2-methylcrotonate), (Z); Nsc93767; 3-(2-methyl-2-butenoate); Cevadine-RM; CEVADINE; Cevane-3,4,12,14,16,17,20-htol,4,9-oxy-, 3-[(2Z)-2-methyl-2-butenoate], (3b,4a,16b); Cevane-3.beta.,4.beta.,12,14,16.beta.,17,20-htol, 4,9-oxy-, 3-(2-methylcrotonate), (Z); utenoate)

物化性质

• 密度: 1.41g/cm3
• 沸点: 733.3ºC at 760 mmHg
• 熔点: 213.5ºC (with decomposition)
• 分子式: C₃₂H₄₉NO₉
• 分子量: 591.73
• 闪点: 397.3ºC
• 精确质量: 591.34100
• PSA: 160.15000
• LogP: 0.92910
• 折射率: 1.647
• 储存条件: 库房低温通风干燥,与食品原料分开存放

生物活性

• 描述: Cevadine 是一种电压敏感钠通道 (sodium channel) 激动剂。Cevadine 具杀虫 (insecticidal) 活性。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 感染
• 参考文献:

  [1]. Bloomquist JR. Ion channels as targets for insecticides. Annu Rev Entomol. 1996;41:163-90.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : FL5600000 CHEMICAL NAME : Cevane-3-beta,4-beta,12,14,16-beta,17,20-heptol, 4,9-epoxy-, 3-(2-methylcrotonate), (Z)- CAS REGISTRY NUMBER : 62-59-9 BEILSTEIN REFERENCE NO. : 0072445 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C32-H49-N-O9 MOLECULAR WEIGHT : 591.82 WISWESSER LINE NOTATION : T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ EQ GQ IQ I1 M1 RQ U1 A&OV1UY1&1 B&Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 76,847,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4900 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 26,383,1946 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 116 mg/kg TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,412,1957 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 26,383,1946

安全

• 危险品运输编码: UN 1544
• 包装等级: II
• 危险类别: 6.1(a)

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