<生产厂家价格>

美海屈林萘二磺酸盐

美海屈林萘二磺酸盐用途

Mebhydrolin napadisylate 是一种特异性组胺 H1 受体拮抗剂。

美海屈林萘二磺酸盐名称

[ CAS 号 ]:
6153-33-9

[ 中文名 ]:
美海屈林萘二磺酸盐

[ 英文名 ]:
Mebhydrolin napadisylate

[中文别名 ]:

[英文别名 ]:

Mebhydroline 1,5-naphthalenedisulfonate salt
diazoline
Mebhydrolin napadisylate
Mebhydroline Napadisylate

美海屈林萘二磺酸盐生物活性

[ 描述 ]:

Mebhydrolin napadisylate 是一种特异性组胺 H1 受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

[ 靶点 ]

Histamine H1-receptor[1]

[体外研究]

Mebhydrolin是一种特异性组胺H1受体拮抗剂,具有极低的镇静作用,并与氯丙嗪(原型吩噻嗪)的作用相比较[1]。 Mebhydrolin在乙醇相互作用研究期间发挥抗组胺作用[2]。

[参考文献]

[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7.

[2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.

[相关活性小分子]

美海屈林萘二磺酸盐物理化学性质

[ 密度 ]:
0.9799 (rough estimate)

[ 沸点 ]:
457.3ºC at 760 mmHg

[ 熔点 ]:
280°C (rough estimate)

[ 分子式 ]:
C₄₈H₄₈N₄O₆S₂

[ 分子量 ]:
841.048

[ 闪点 ]:
230.4ºC

[ 精确质量 ]:
840.301514

[ PSA ]:
141.84000

[ LogP ]:
10.72560

[ 外观性状 ]:
白色或近乎于白色结晶

[ 折射率 ]:
1.8676 (estimate)

[ 储存条件 ]:
室温，惰性气体

美海屈林萘二磺酸盐MSDS

详细MSDS(安全技术说明书)

美海屈林萘二磺酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6845000

CAS REGISTRY NUMBER :: 6153-33-9

LAST UPDATED :: 198706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H20-N2.1/2C10-H8-O6-S2

MOLECULAR WEIGHT :: 420.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,539,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,850,1982

美海屈林萘二磺酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QJ6845000

[ 海关编码 ]:
2933990090

美海屈林萘二磺酸盐海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

美海屈林萘二磺酸盐文献

Three explorative studies on the efficacy of the antihistamine mebhydroline (Omeril).

Int. J. Clin. Pharmacol. Ther. 33 , 373, (1995)

The efficacy of a multiple oral dose treatment with mebhydroline (Omeril coated tablets, 100 mg t.i.d.) was examined in 3 studies which were performed in a randomized, double-blind and placebo-control...

Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan.

Gastroenterology 135(1) , 111-21, (2008)

This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C v...

[Agranulocytosis associated with mebhydrolin napadisylate (Incidal)].

Harefuah 106(5) , 208-9, (1984)

更多文献