盐酸阿拉考特酯

盐酸阿拉考特酯用途

Alaproclate (GEA 654) hydrochloride 是一种选择性、具有口服活性的 serotonin 再摄取抑制剂 (SSRI)。Alaproclate hydrochloride 也是一种有效的、可逆的、非竞争性的 NMDA 受体拮抗剂。

盐酸阿拉考特酯名称

[ CAS 号 ]:
60719-83-7

[ 中文名 ]:
盐酸阿拉考特酯

[ 英文名 ]:
Alaproclate HCl

[英文别名 ]:

盐酸阿拉考特酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. Campagna J, et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 Dec 4;8(1):17574.

[2]. Wilkinson A, et al. Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.

盐酸阿拉考特酯物理化学性质

[ 沸点 ]:
324.8ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₉Cl₂NO₂

[ 分子量 ]:
292.20

[ 闪点 ]:
150.2ºC

[ 精确质量 ]:
291.07900

[ PSA ]:
52.32000

[ LogP ]:
4.05380

盐酸阿拉考特酯MSDS

详细MSDS(安全技术说明书)

盐酸阿拉考特酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4397300

CHEMICAL NAME :: DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 60719-83-7

LAST UPDATED :: 199403

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H18-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 292.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 901 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

盐酸阿拉考特酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
AY4397300

盐酸阿拉考特酯文献

The effects of increased serotonergic and decreased cholinergic activities on spatial navigation performance in rats.

Pharmacol. Biochem. Behav. 39(1) , 25-9, (1991)

In the present set of experiments the effects of a serotonin (5-HT) reuptake blocker, alaproclate (alap) and of a muscarinic antagonist, scopolamine (scop) on place navigation (hidden platform) and cu...

The effects of alaproclate and p-chlorophenylalanine on cued navigation performance in rats.

J. Neural Transm. Park. Dis. Dement. Sect. 4(1) , 43-52, (1992)

The present study investigates the effects of a serotonin (5-HT) reuptake inhibitor, alaproclate, on water maze cued navigation performance in serotonin depleted and control rats. Treatment with p-chl...

Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate.

Psychopharmacology 103(4) , 567-70, (1991)

The present studies investigates the effects of a 5HT3-antagonist (ondansetron: 0.01, 0.1, 1, 10 micrograms), a 5HT2-antagonist (methysergide: 2, 10, 20 mg/kg) and a serotonin uptake inhibitor (alapro...

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