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氯吡拉敏

氯吡拉敏用途

氯吡胺是竞争性可逆H1受体拮抗剂。氯吡喃胺对乳腺癌也有抗肿瘤活性。氯吡喃胺可用于研究过敏性疾病,如结膜炎和支气管哮喘[1][2]。

氯吡拉敏名称

[ CAS 号 ]:
59-32-5

[ 中文名 ]:
氯吡拉敏

[ 英文名 ]:
Chloropyramine

[中文别名 ]:

氯吡胺

[英文别名 ]:

Chlorneoantergan
Avapena
Halopyramine
Anaphylline
Suprastin
Synpen
Synopen
Chloropyramine
Chlorpyraminum
Chlorpyramine

氯吡拉敏生物活性

[ 描述 ]:

氯吡胺是竞争性可逆H1受体拮抗剂。氯吡喃胺对乳腺癌也有抗肿瘤活性。氯吡喃胺可用于研究过敏性疾病,如结膜炎和支气管哮喘[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 心血管疾病

信号通路 >> 免疫及炎症 >> 组胺受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

H1 Receptor

[体外研究]

氯吡喃胺(25,50μM；24小时,48小时)诱导乳腺癌细胞系中SASH1的表达和凋亡[1]。Western Blot分析[1]细胞系：乳腺癌细胞系浓度：25或50μ。凋亡分析[1]细胞系：T47D、MDA-MB-231和BT-54细胞浓度：50μM培养时间：48小时结果：诱导乳腺癌细胞系凋亡。

[体内研究]

氯吡拉明(i.p.；10 mg/kg)消除大鼠体温过低[2]。动物模型：大鼠[2]剂量：10 mg/kg给药：腹膜内结果：降低组胺诱导的低温。

氯吡拉敏物理化学性质

[ 密度 ]:
1.158g/cm3

[ 沸点 ]:
413.5ºC at 760 mmHg

[ 熔点 ]:
25°C

[ 分子式 ]:
C₁₆H₂₀ClN₃

[ 分子量 ]:
289.80300

[ 闪点 ]:
203.9ºC

[ 精确质量 ]:
289.13500

[ PSA ]:
19.37000

[ LogP ]:
3.30320

[ 折射率 ]:
1.6

[ 储存条件 ]:
2-8°C

氯吡拉敏MSDS

详细MSDS(安全技术说明书)

氯吡拉敏毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US6320000

CHEMICAL NAME :: Pyridine, 2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-

CAS REGISTRY NUMBER :: 59-32-5

BEILSTEIN REFERENCE NO. :: 0257085

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C16-H20-Cl-N3

MOLECULAR WEIGHT :: 289.84

WISWESSER LINE NOTATION :: T6NJ BN2N1&1&1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 354 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79200 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24100 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 142 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,131,1957

氯吡拉敏安全信息

[ 危害码 (欧洲) ]:
Xi