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盐酸羟胺

盐酸羟胺用途

Hydroxyamine hydrochloride 是一种选择性单胺氧化酶 (MAO) 抑制剂,可用于抑制血小板聚集。Hydroxyamine hydrochloride 是有机合成的中间体。

盐酸羟胺作用

用作医药和有机合成的原料

盐酸羟胺名称

[ CAS 号 ]:
5470-11-1

[ 中文名 ]:
盐酸羟胺

[ 英文名 ]:
Hydroxyamine hydrochloride

[中文别名 ]:

[英文别名 ]:

EINECS 226-798-2
MFCD00051089
Hydroxylammonium chloride
Ammonium, hydroxy-, chloride (1:1)
hydroxylamine,hydrochloride

盐酸羟胺生物活性

[ 描述 ]:

Hydroxyamine hydrochloride 是一种选择性单胺氧化酶 (MAO) 抑制剂,可用于抑制血小板聚集。Hydroxyamine hydrochloride 是有机合成的中间体。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 神经信号通路 >> 单胺氧化酶

[体外研究]

盐酸羟胺(1mm)抑制MAO活性达99.8%[1]。

[参考文献]

[1]. Roh JH, et al. Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12. Biosci Biotechnol Biochem. 1994 Sep;58(9):1652-6.

盐酸羟胺物理化学性质

[ 密度 ]:
1.67 g/mL at 25 °C(lit.)

[ 沸点 ]:
56.5ºC at 760mmHg

[ 熔点 ]:
155-157 °C (dec.)(lit.)

[ 分子式 ]:
ClH₄NO

[ 分子量 ]:
69.491

[ 精确质量 ]:
68.998138

[ PSA ]:
46.25000

[ LogP ]:
0.83660

[ 外观性状 ]:
无色或灰白色结晶固体

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Substances to be avoided include strong oxidizing agents. Heating above 115 C may cause explosion; do not store above 65C. Moisture and air sensitive.

[ 水溶解性 ]:
560 g/L (20 ºC)

盐酸羟胺MSDS

盐酸羟胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NC3675000

CHEMICAL NAME :: Hydroxylamine, hydrochloride

CAS REGISTRY NUMBER :: 5470-11-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: Cl-H.H3-N-O

MOLECULAR WEIGHT :: 69.50

WISWESSER LINE NOTATION :: ZQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 141 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 408 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 49500 mg/kg/25W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thyroid weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2478 mg/kg/6D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 25 mg/L

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 20,726,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 38950 No. of Facilities: 1202 (estimated) No. of Industries: 18 No. of Occupations: 11 No. of Employees: 6578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 38950 No. of Facilities: 1258 (estimated) No. of Industries: 20 No. of Occupations: 26 No. of Employees: 15258 (estimated) No. of Female Employees: 4469 (estimated)

盐酸羟胺安全信息

[ 符号 ]:

GHS05, GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H290-H302 + H312-H315-H317-H319-H351-H373-H410

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/38;R43;R48/22;R50

[ 安全声明 (欧洲) ]:
S22-S24-S37-S61

[ 危险品运输编码 ]:
UN 2923 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
NC3675000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2935009090

盐酸羟胺合成路线

盐酸羟胺上下游产品

盐酸羟胺上游产品

盐酸羟胺下游产品

盐酸羟胺制备

1.亚硝酸钠合成法（肟化法）将水加入反应釜，搅拌下加入亚硝酸钠，分次加入焦亚硫酸钠，然后用硫酸酸化。将酸化后的物料送入水解釜，加入丙酮，再用液碱中和，将中和液蒸馏，得丙酮肟。将丙酮肟和盐酸加入成盐釜中反应，生成盐酸羟胺和丙酮。丙酮回收使用；盐酸羟胺经浓缩、冷却结晶、离心分离、干燥，即得成品。其反应式如下：原料消耗定额：亚硝酸钠（95%）1970kg/t、焦亚硫酸钠（以SO2计64%）5418kg/t、丙酮（98%）1175kg/t。2.硝基甲烷法硝基甲烷与盐酸、水作用以制得盐酸羟胺。按HGB3044-76，盐酸羟胺产品为白色结晶，二级品含量≥98.5，三级品含量≥97%。原料消耗定额：硝基甲烷1200kg/t、盐酸（30%）1500kg/t。 2. 在亚硝酸钠的水溶液中，分次加入一定量的焦亚硫酸钠，然后用硫酸酸化。酸化后的料液送入水解釜，加一定量的丙酮，然后用碱中和。中和液经蒸馏得到丙酮肟。丙酮肟和盐酸反应生成盐酸羟胺和丙酮。盐酸羟胺达到一定浓度后，进行冷却结晶、离心分离、干燥即可。或者由硝基甲烷与盐酸、水作用以制得盐酸羟胺。 3. 亚硝酸钠加水溶解，降温至0℃，加入亚硫酸氢钠和35%～40%的稀硫酸使溶液ph＝2，加丙酮温度升至35℃时，停止搅拌，温升至70℃保温3h，降温至30℃，加氢氧化钠溶液至ph值7～8。加热将丙酮肟蒸出，加入盐酸，维持温度55～60℃，保温12h，然后进行浓缩。稍冷后脱色，过滤，再浓缩、冷却、结晶，则得成品。过程反应式：精制可采取乙醇浸泡或水重结晶。

盐酸羟胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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