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QX-314氯化物(氯化N-乙卡因碱)(mM/ml)

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)用途

QX-314 chloride 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)名称

[ CAS 号 ]:
5369-03-9

[ 中文名 ]:
N-(2,6-二甲基苯基氨基甲酰甲基)三乙基氯化胺

[ 英文名 ]:
QX 314 chloride

[英文别名 ]:

Lidocaine N-ethyl chloride
lidocaine ethochloride
QX 314 chloride

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)生物活性

[ 描述 ]:

QX-314 chloride 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 神经疾病

[ 靶点 ]

sodium channel[1]

[体外研究]

氯化QX-314在体外对瞬时受体电位香草醛1型通道(TRPV1)具有双相作用[2]。QX-314氯化物(1–60 mM)以浓度依赖的方式直接激活TRPV1[2]。氯化QX-314(10mm)抑制海马CA1区锥体神经元胞内钙电流,低阈值(T型)钙电流平均小于控制振幅的45%。

[参考文献]

[1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34.

[2]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)物理化学性质

[ 熔点 ]:
209-211 °C

[ 分子式 ]:
C₁₆H₂₇ClN₂O

[ 分子量 ]:
298.85100

[ 精确质量 ]:
298.18100

[ PSA ]:
29.10000

[ LogP ]:
0.19540

[ 储存条件 ]:
2-8°C

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BT0430000

CHEMICAL NAME :: Ammonium, triethyl((2,6-xylylcarbamoyl)methyl)-, chloride

CAS REGISTRY NUMBER :: 5369-03-9

LAST UPDATED :: 198806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H27-N2-O.Cl

MOLECULAR WEIGHT :: 298.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 2,213,1965

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2924299090

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)合成路线

详细合成路线

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)上下游产品

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QX-314氯化物(氯化N-乙卡因碱)(mM/ml)下游产品

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

QX-314氯化物(氯化N-乙卡因碱)(mM/ml)文献

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