苦参碱

苦参碱用途

Matrine(Sophocarpidine; α-Matrine)是来源于植物的生物碱,有抗肿瘤活性,是kappa阿片受体激动剂。

苦参碱作用

0.3%～1%苦参碱溶液对乙型链球菌、痢疾杆菌、变形杆菌、大肠杆菌、金黄色葡葡球菌、绿脓杆菌均有较强的抑制作用，7.5%～10%的氧化苦参碱对痢疾、大肠杆菌、金黄色葡葡球菌、乙型链球菌也有抑制作用。另有报道苦参总碱对结核杆菌、霍乱弧菌、麻风杆菌、皮肤致病性真菌及钩端螺旋体等病原体也都有一定抑制杀灭作用。另外，山豆根水煎剂中含有抗Cox B5病毒的活性物质。具有一定的抗病毒作用。

苦参碱物理化学性质密度：1.16g/cm³
沸点：396.7°C at 760 mmHg
闪点：172.7°C
蒸汽压：1.67E-06mmHg at 25°C

苦参碱名称

[ CAS 号 ]:
519-02-8

[ 中文名 ]:
苦参碱

[ 英文名 ]:
Matrine

[中文别名 ]:

[英文别名 ]:

Maca extract
Matrine
Matrines
Matridin-15-on
EINECS 610-750-6
MATRINIUM
MATRENE
Sophocarpidine
MASSMARK 1621
matridin-15-one

苦参碱生物活性

[ 描述 ]:

Matrine(Sophocarpidine; α-Matrine)是来源于植物的生物碱,有抗肿瘤活性,是kappa阿片受体激动剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

天然产物 >> 生物碱

研究领域 >> 癌症

[参考文献]

[1]. Luo C, et al. Inhibition of matrine against gastric cancer cell line MNK45 growth and its anti-tumor mechanism. Mol Biol Rep. 2012 May;39(5):5459-64.

[2]. Tan C, et al. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep. 2013 Nov;30(5):2529-35.

[3]. Li X, et al. Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats. J Pharm Pharmacol. 2012 Aug;64(8):1107-18.

[4]. Zhang B, et al. Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice. Eur J Pharm Sci. 2011 Dec 18;44(5):573-9.

[相关活性小分子]

苦参碱物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
396.7±31.0 °C at 760 mmHg

[ 熔点 ]:
77°C

[ 分子式 ]:
C₁₅H₂₄N₂O

[ 分子量 ]:
248.364

[ 闪点 ]:
172.7±17.2 °C

[ 精确质量 ]:
248.188858

[ PSA ]:
23.55000

[ LogP ]:
1.44

[ 外观性状 ]:
白色至黄色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.581

[ 储存条件 ]:
库房低温,通风,干燥

苦参碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OQ1754000

CHEMICAL NAME :: Matrine

CAS REGISTRY NUMBER :: 519-02-8

BEILSTEIN REFERENCE NO. :: 0085851

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H24-N2-O

MOLECULAR WEIGHT :: 248.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 18,2555,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 18,214,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64850 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74150 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992

苦参碱安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
22-26-36/37/39-45

[ 海关编码 ]:
1302199001

苦参碱合成路线

详细合成路线

苦参碱上下游产品

苦参碱上游产品

苦参碱下游产品

苦参碱制备

1.存在于豆科植物苦参（Sophoraflavescens）的根中，在苦豆子（Sophoraalopecuroides）、山豆根（Sophora subprostrata）等植物中也有分布。制备工艺：植物原料—粉碎—萃取—调配制得。

苦参碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苦参碱