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NS1643

NS1643用途

NS1643是hERG高效抑制剂,EC50值10.5uM。

NS1643名称

[ CAS 号 ]:
448895-37-2

[ 中文名 ]:
1,3-双(2-羟基-5-(三氟甲基)苯基)脲

[ 英文名 ]:
NS-1643

[英文别名 ]:

ns1643
NS-1643

NS1643生物活性

[ 描述 ]:

NS1643是hERG高效抑制剂,EC50值10.5uM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 其他

[参考文献]

[1]. Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65.

[2]. Hansen RS, et al. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol Pharmacol. 2006 Jan;69(1):266-77.

[3]. Elmedyb P, et al. Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology. 2007 Aug;53(2):283-94.

[相关活性小分子]

NS1643物理化学性质

[ 密度 ]:
1.627g/cm3

[ 沸点 ]:
342.311ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₁₀F₆N₂O₃

[ 分子量 ]:
380.24200

[ 闪点 ]:
160.824ºC

[ 精确质量 ]:
380.06000

[ PSA ]:
81.59000

[ LogP ]:
4.92540

[ 外观性状 ]:
white solid

[ 折射率 ]:
1.589

[ 储存条件 ]:
-20℃

NS1643MSDS

详细MSDS(安全技术说明书)

NS1643安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

NS1643文献

The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.

J. Pharmacol. Exp. Ther. , (2014)

Human ether-a-go-go-related gene (hERG) and KCNQ channels are two classes of voltage-gated potassium channels. Specific mutations have been identified that are causal for type II long QT (LQT2) syndro...

Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.

J. Neurosci. 36 , 2769-81, (2016)

DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal link between TET dysregu...

Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

Cell Death Dis. 4 , e652, (2013)

Traditionally the hERG1 potassium channel has been known to have a fundamental role in membrane excitability of several mammalian cells including cardiac myocytes. hERG1 has recently been found to be ...

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